A/Prof Kate Schroder

 

A/Prof Kate Schroder

 

Principal Investigator, Inflammasome Lab
Deputy Director, IMB Centre for Inflammation Research
NHMRC RD Wright Fellow

 

 

 

A/Prof Kate Schroder heads the Inflammasome Laboratory as an NHMRC RD Wright Fellow. Kate received her PhD in 2005 for her research investigating mechanisms of macrophage activation, in the laboratory of David Hume. Her subsequent postdoctoral position with David Hume and Matthew Sweet investigated the transcriptional programs triggered by macrophage differentiation and activation. A key focus of her postdoctoral studies was to define species differences in the innate immune responses of human versus mouse macrophages. During her NHMRC CJ Martin Fellowship in Jürg Tschopp's group in Switzerland, Kate gained expertise in inflammasome biology. Her current research interests include the molecular mechanisms governing inflammasome activity and caspase activation, the evolutionary biology of inflammasomes, and the cellular mediators of inflammasome-dependent inflammation.

 

Inflammasomes provide a molecular platform for cluster-dependent activation of the protease, caspase-1, and thereby elicit a proteolytic signalling pathway that triggers the processing and secretion of proinflammatory mediators, and drives inflammatory cell death. These pathways culminate in immune system activation (inflammation), the induction of antimicrobial defence mechanisms, and microbial elimination. Inflammasomes can also be triggered by non-microbial structures (e.g. host molecules indicating cell stress or injury) and can thereby drive unhealthy inflammation in human disease. Genetic mutations in inflammasome components are associated with human heritable inflammatory disorders, and recent studies have identified an unexpected role for inflammasome-dependent cytokines in driving the inflammatory component of numerous chronic diseases (e.g. gout, diabetes, Alzheimer's disease).

 

The Inflammasome Lab integrates molecular and cell biology approaches with in vivo studies to gain a holistic understanding of inflammasome function during infection, and inflammasome dysfunction in human inflammatory disease. Our recent studies have yielded exciting new insights into the mechanisms governing inflammasome-mediated inflammation in vitro and in vivo.

 

CONTACTS AND LINKS


 

Email: k.schroder@imb.uq.edu.au

Telephone: +61 7 3346 2058
 

Institute for Molecular Bioscience

The University of Queensland, UQ Researcher

Australian Infectious Diseases Research Centre (AID)

Australasian Society for Immunology Inc.

Researcher ID

Google Scholar

Research Gate

ORCID

Twitter

 

AWARDS, PUBLICATIONS AND PATENTS


 

 

MAJOR AWARDS

 

2014 Seymour & Vivian Milstein Young Investigator Award for notable contributions to basic research, International Cytokine and Interferon Society

 

2013 Tall Poppy Science Award, Australian Institute of Policy and Science

 

2013 Research Excellence Award, UQ Foundation

 

2013 Queensland Premier’s Award, Queensland Health And Medical Research Award (Runner-up, Senior Researcher), Australian Society for Medical Research

 

2012 Gordon Ada Career Mid-Career Development Award, Australasian Society for Immunology

 

2010 Queensland Premier’s Award, Queensland Health And Medical Research Award (Winner, post-doctoral category), Australian Society for Medical Research

 

2008 Dolph Adams Award for the most highly cited review in 2003-2008, for Schroder et al. (2004) 75:163-89, Journal of Leukocyte Biology

 

2005 Young Investigator Award, European Macrophage and Dendritic Cell Society

 

EDUCATION

 

2005 PhD (Immunology), The University of Queensland

 

1999 Honours 1st Class, The University of Queensland

 

1998 BSc, The University of Queensland

 

 

90. Ramnath D, Irvine KM, Lukowski SW, Horsfall LU, Loh Z, Clouston AD, Patel PJ, Fagan KJ, Iyer A, Lampe G, Stow JL, Schroder K, Fairlie DP, Powell JE, Powell EE, Sweet MJ. (2018).
Hepatic expression profiling identifies steatosis-independent and steatosis-driven advanced fibrosis genes. JCI Insight In press. Pubmed

 

89. Deretic V, Prossnitz E, Burge M, Campen MJ, Cannon J, Liu KJ, Sklar LA, Allers L, Garcia SA, Baehrecke EH, Behrends C, Cecconi F, Codogno P, Chen GC, Elazar Z, Eskelinen EL, Fourie B, Gozuacik D, Hong W, Hotamisligi G, Jäättelä M, Jo EK, Johansen T, Juhász G, Kimchi A, Ktistakis N, Kroemer G, MIzushima N, Münz C, Reggiori F, Rubinsztein D, Ryan K, Schroder K, Simonsen A, Tooze S, Vaccaro M, Yoshimori T, Yu L, Zhang H, Klionsky DJ. (2018).
Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations. Autophagy In press. Pubmed

 

88. Perera AP, Fernando R, Shinde T, Gundamaraju R, Southam B, Sohal SS, Robertson AAB, Schroder K, Kunde D, Eri R. (2018).
MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. Scientific Reports Jun 5;8(1):8618. Pubmed

 

87. Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica J, Vince JE, Schroder K. (2018).
Cutting edge: IAP inhibition sensitizes neutrophils to TNF but not LPS-mediated cell death and IL-1β secretion. Journal of Immunology May 15;200(10):3341-3346. Pubmed

 

86. Gambin Y, Giles N, O'Carroll A, Polinkovsky ME, Johnston W, Hunter DJB, Alexandrov K, Schroder K, Sierecki E. (2018).
Single-Molecule Fluorescence Reveals the Oligomerisation and Folding Steps Driving the Prion-like Behaviour of ASC. Journal of Molecular Biology Feb 16;430(4):491-508. Pubmed

 

85. Chen AC, Tran HB, Xi Y, Yerkovich ST, Baines KJ, Pizzutto SJ, Carroll M, Robertson AAB, Cooper MA, Schroder K, Simpson JL, Gibson PG, Hodge G, Masters IB, Buntain HM, Petsky HL, Prime SJ, Chang AB, Hodge S, Upham JW. (2018).
Multiple inflammasomes may regulate the interleukin-1-driven inflammation in protracted bacterial bronchitis. ERJ Open Research Mar 23;4(1). Pubmed

 

84. Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS, Schroder K. (2018).
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine Mar 5;215(3):827-840. Pubmed
1Equal contribution

See Journal of Experimental Medicine for a complete list of citations, reviews and media attention this publication has recieved. Read the news articles here

Reseach Highlight:
Defusing inflammasomes. Sandstrom A, Vance RE. Journal of Experimental Medicine. Pubmed

 

83. James KR, Soon MSF, Sebina I, Fernandez-Ruiz D, Davey G, Liligeto UN, Nair AS, Fogg LG, Edwards CL, Best SE, Lansink LIM, Schroder K, Wilson JAC, Austin R, Suhrbier A, Lane SW, Hill GR, Engwerda CR, Heath WR, Haque A. (2018).
IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection. Journal of Immunology Feb 15;200(4):1443-1456. Pubmed

 

82. Boucher D, Chan A, Ross C, Schroder K. (2018).
Quantifying Caspase-1 Activity in Murine Macrophages. Methods in Molecular Biology 1725:163-176. Pubmed

 

81. Schroder K, Kanneganti TD, Shao F, Broz P. (2018).
Mechanisms and Consequences of Inflammasome Activation. Journal of Molecular Biology Jan 19;430(2):131-132. Pubmed

 

80. Hill JR, Coll RC, Sue N, Reid JC, Dou J, Holley CL, Pelingon R, Dickinson JB, Biden TJ, Schroder K, Cooper MA, Robertson AAB. (2017).
Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors. Chem Med Chem Sep 7;12(17):1449-1457. Pubmed

 

79. Lawlor KE, Feltham R, Yabal M, Conos SA, Chen KW, Ziehe S, Graß C, Zhan Y, Nguyen TA, Hall C, Vince AJ, Chatfield SM, D'Silva DB, Pang KC, Schroder K, Silke J, Vaux DL, Jost PJ, Vince JE. (2017).
XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1β Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation. Cell Reports Jul 18;20(3):668-682. Pubmed

 

78. Mridha AR, Wree A, Robertson AA, Yeh MM, Johnson CD, Van Rooyen DM, Haczeyni F, Teoh NC, Savard C, Ioannou GN, Masters SL, Schroder K, Cooper MA, Feldstein AE, Farrell GC. (2017).
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology 2017 May;66(5):1037-1046. Pubmed

Reseach Highlight:
A critical role for the NLRP3 inflammasome in NASH. Hugh Thomas. Nature Reviews Gastroenterology and Hepatology Nature

 

77. Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE. (2017).
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A Feb7;114(6):E961-969. Pubmed

 

76. Bezbradica JS1, Coll R1, Schroder K (2017).
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals. Cellular & Molecular Immunology. 14:118-126. 1Joint contribution. Pubmed

 

75. Deuis JR, Yin K, Cooper MA, Schroder K, Vetter I. (2017).
Role of NLRP3 inflammasome in a model of acute burn-induced pain. Burns Mar;43(2):304-309. Pubmed

 

74. Bezbradica JS, Schroder K. (2017).
Zebrafish earns its stripes for in vivo ASC speck dynamics. Journal of Cell Biology Sep 4;216(9):2615-2618. Pubmed

 

73. Duszyc K, Gomez GA, Schroder K, Sweet MJ, Yap AS. (2017).
In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis. Tissue Barriers Oct 2;5(4):e1345353. Pubmed

 

72. Bierschenk D, Boucher D, Schroder K. (2017).
Salmonella-induced inflammasome activation in humans. Molecular Immunology Jun;86:38-43. Pubmed

 

71. Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AA, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O. (2016).
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting  Mitochondria. Immunity. Oct 18;45(4):761-773. Pubmed

 

70. Sester DP, Zamoshnikova A, Thygesen SJ, Vajjhala PR, Cridland SO, Schroder K, Stacey KJ. (2016).
Assessment of inflammasome formation by flow cytometry. Current Protocols in Immunology Aug1;114:14.40.1-14.40.29. Pubmed

 

69. Le TT, Skak K, Schroder K, Schroder WA, Boyle GM, Pierce CJ, Suhrbier A. (2016).
IL-1 contributes to the anti-cancer efficacy of ingenol mebutate. PLoS One Apr 21;11(4):e0153975. Pubmed

 

68. Masters SL, Lagou V, Jéru I, Baker PJ, Van Eyck L, Parry DA, Lawless D, De Nardo D, Garcia-Perez JE, Dagley LF, Holley CL, Dooley J, Moghaddas F, Pasciuto E, Jeandel PY, Sciot R, Lyras D, Webb AI, Nicholson SE, De Somer L, van Nieuwenhove E, Ruuth-Praz J, Copin B, Cochet E, Medlej-Hashim M, Megarbane A, Schroder K, Savic S, Goris A, Amselem S, Wouters C, Liston A (2016).
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. Science Translational Medicine Mar 30;8(332):332ra45. Pubmed

Comment in:
Mutation implicated in auto-inflammatory disease. Nature Middle East

 

67. Kapetanovic R, Bokil NJ, Achard ME, Ong CY, Peters KM, Stocks CJ, Phan MD, Monteleone M, Schroder K, Irvine KM, Saunders BM, Walker MJ, Stacey KJ, McEwan AG, Schembri MA, Sweet MJ (2016).
Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal May;30(5):1901-12. Pubmed

 

66. Arrifin JK, Kapetanovic R, Schaale K, Gatica-Andrades M, Blumenthal A, Schroder K, Sweet MJ (2016).
The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression. Journal of Leukocyte Biology Jul;100(1):155-61. Pubmed

 

65. Chen KW, Bezbradica JS, Gross CJ, Wall AA, Sweet MJ, Stow JL, Schroder K (2016).
The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists. European Journal of Immunology 46(4):1004-10. Pubmed

 

64. Zamoshnikova A, Groß CJ, Schuster S, Chen KW, Wilson A, Tacchini-Cottier F, Schroder K (2016).
NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling. Immunobiology 221(2):341-6. Pubmed

 

63. Schaale K, Peters KM, Murthy AM, Fritzsche A, Phan MD, Totsika M, Robertson AAB, Nichols KB, Cooper MC, Stacey KJ, Ulett GC, Schroder K, Schembri MA, Sweet MJ (2016).
Strain-and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli. Mucosal Immunology 9(1):124-36. Pubmed

 

62. Coll R, O'Neill L, Schroder K (2016).
Questions and Controversies in innate immune research: What is the physiological role of NLRP3? Cell Death Discovery Apr 4;2:16019. Cell Death Discovery

 

61.  Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ (2015).
The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments. Journal of Biological Chemistry 290(49):29217-30. Pubmed

 

60. Kimura T, Jain A, Choi SW, Mandell MA, Schroder K, Johansen T, Deretic V (2015).
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. Journal of Cell Biology 210(6):973-89. Pubmed

 

59. Baker PJ1, Boucher D1, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K2, Masters SL2 (2015).
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology 45:2918-26. 1, 2Joint Contribution. Pubmed

Comment in:
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. European Journal of Immunology

 

58. Sester DP, Sagulenko V, Thygesen SJ, Cridland JA, Loi YS, Cridland SO, Masters SL, Genske U, Hornung V, Andoniou CE, Sweet MJ, Degli-Esposti MA, Schroder K, Stacey KJ (2015).
Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice. Journal of Immunology 195(3):1233-41. Pubmed

 

57. Zeis T, Allaman I, Gentner M, Schroder K, Tschopp J, Magistretti PJ, Schaeren-Wiemers N (2015).
Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling. Brain, Behavior, Immunity 48:313-25. Pubmed

 

56. Coll RC, Robertson AAB, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KHG, Masters SL, Schroder K, Cooper MA, O’Neill LAJ (2015).
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine 21(3):248-55. Pubmed

See Nature Medicine for a complete list of citations, reviews and media attention this publication has recieved. Read the news articles here

Comment in:
Inflammasome inhibition: putting out the fire. Cell Metabolism
Inflammasome: starving inflammation. Nature Reviews Drug Discovery
Potent small molecule extinguishes the NLRP3 inflammasome. Nature Reviews Rheumatology
The Nlrp3 inflammasome admits defeat. Trends in Immunology
Inflammasome: starving inflammation. Nature Reviews Immunology
Targeting neuroinflammation through inhibition of NLRP3. Nature Reviews Neurology
Taming the Inflammasome. Nature Medicine

 

55. Sester DP, Thygesen SJ, Sagulenko V, Vajjhala PR, Cridland JA, Vitak N, Chen KW, Osborne GW, Schroder K, Stacey KJ (2015).
A novel flow cytometric method to assess inflammasome formation. Journal of Immunology 194(1):455-462. Pubmed

 

54. Monteleone M, Stow J, Schroder K (2015).
Mechanisms of unconventional secretion of IL-1 family cytokines. Cytokine 74(2):213-8. Pubmed

 

53. Boucher DB, Chen KW, Schroder K (2015).
Burn the house, save the day: pyroptosis in pathogen restriction. Inflammasome 2: 1-6. Inflammasome

 

52. Chen KW, Gross CJ, Sotomayor F, Stacey KJ, Tschopp J, Sweet MJ, Schroder K (2014).
The neutrophil NLRC4 inflammasome selectively promotes IL-1b maturation without pyroptosis during acute Salmonella challenge. Cell Reports 8: 570-582. Pubmed

 

51. Luo L, Wall AA, Yeo JC, Condon ND, Norwood SJ, Schoenwaelder S, Chen KW, Jackson S, Jenkins BJ, Hartland EL, Schroder K, Collins BM, Sweet MJ, Stow JL (2014).
Rab8a interacts directly with PI3Kg to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications 5:4407. Pubmed

 

50. Traini M, Quinn CM, Sandoval C, Johansson E, Schroder K, Kockx M, Meikle PJ, Jessup W, Kritharides L (2014).
Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. Journal of Biological Chemistry 289: 32895-32913. Pubmed

 

49. Bezbradica JS, Schroder K (2014).
TRAF6 is a nexus for TLR-STAT1 crosstalk. Immunology and Cell Biology 92: 737-738. Pubmed

Comment on:
STAT1 plays a role in TLR signal transduction and infammatory responses. Luu K et al 2014 Immunol Cell Biol.

 

48. Chen KW, Richards AA, Zamoshnikova A, Schroder K (2014).
Inflammasomes and inflammation. Chapter 8 in Cancer and Inflammation Mechanisms, Y. Hiraku, S. Kawanishi, H. Ohshima (Editors). (USA: John Wiley and Sons, Inc). Wiley

 

47. Sagulenko V, Thygesen SJ, Sester DP, Idris A, Cridland JA, Vajjhala PR, Roberts TL, Schroder K, Vince JE, Hill JM, Silke J, Stacey KJ (2013).
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death and Differentiation 20: 1149-1160. Pubmed

Comment in:
dsDNA ASCs for caspase 8-mediated apoptosis. Cell Death Differ.
Another twist in the on and off affair between cell suicide and inflammation. Cell Death Differ.

 

46. Achard MES, Chen KW, Sweet MJ, Watts RE, Schroder K, Schembri MA, McEwan AG (2013).
An antioxidant role for catecholate siderophores in Salmonella. Biochemical Journal 454: 543-549. Pubmed

 

45. Shakespear MR, Hohenhaus DM, Kelly GM, Kamal NA, Gupta P, Labzin LI, Schroder K, Garceau V, Barbero S, Iyer A, Hume DA, Reid RC, Irvine KM, Fairlie DP, Sweet MJ (2013).
Histone deacetylase 7 promotes toll-like receptor 4-dependent proinflammatory gene expression in macrophages. Journal of Biological Chemistry 288: 25362-25374. Pubmed

 

44. Chen K, Richards AA, Caradoc-Davies TT, Vajjhala PR, Robin G Lua LHL, Hill JH, Schroder K, Sweet MJ, Kellie S, Kobe B, Martin JL (2013).
Human BinCARD splice isoforms have differing localizations and their CARD structure reveals a possible redox role. Acta Crystallographica D 69: 774-784. Pubmed

 

43. Chen KW, Schroder K (2013).
Antimicrobial functions of inflammasomes. Current Opinion in Microbiology 16: 311-318. Pubmed

 

42. Thomas CJ, Schroder K (2013).
Pattern recognition receptor function in neutrophils. Trends in Immunology 34:317-328. Pubmed

 

41. Schroder K and Deretic V (2013).
Innate immunity, the constant gardener of antimicrobial defense.  Current Opinion in Microbiology 16: 293-295. Pubmed

 

40. Schroder K, Sagulenko V, Zamoshnikova A, Richards AA, Cridland JA, Irvine KM, Stacey KJ, Sweet MJ (2012).
Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology 217: 1325-1329. Pubmed

 

39. Schroder K, Irvine KM, Taylor MS, Bokil NJ, Le Cao KA, Masterman KA, Labzin LI, Semple CA, Kapetanovic R, Fairbairn L, Akalin A, Faulkner GJ, Baillie JK, Gongora M, Daub CO, Kawaji H, McLachlan GJ, Goldman N, Grimmond SM, Carninci P, Suzuki H, Hayashizaki Y, Lenhard B, Hume DA, Sweet MJ (2012).
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences U S A 109: E944-53. Pubmed

Subject of a Nature Asia commentary

 

38. Cridland JA, Curley EZ, Wykes MN, Schroder K, Sweet MJ, Roberts TL, Ragan MA, Kassahn KS, Stacey KJ (2012).
The mammalian PYHIN gene family: phylogeny, evolution and expression. BMC Evolutionary Biology 12: 140. Pubmed

 

37. Staehli F, Ludigs K, Heinz L.X, Seguin-Estevez Q, Ferrero I, Braun M, Schroder K, Rebsamen M, Tardivel A, Mattmann C, Macdonald H.R, Romero P, Reith W, Guarda G, Tschopp J (2012).
NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells. Journal of Immunology 188: 3820-3828. Pubmed

 

36. Heinz LX, Rebsamen M, Rossi DC, Staehli F, Schroder K, Quadroni M, Gross O, Schneider P, Tschopp J (2012).
The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. Cell Death and Differentiation 19: 722-731. Pubmed

 

35. Irvine KM, Schroder K, and Powell EE (2012).
Liver repercussions of defective gut surveillance. Hepatology 56: 1174-1177. Pubmed

Comment on:
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature

 

34. Heinz LX, Schroder K (2012).
Novel insights into the innate immune response to non-tuberculous Mycobacteria. Immunology and Cell Biology 90: 568-570. Pubmed

Comment on:
Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1. Lee et al 2012 Immunology and Cellular Biology

 

33. Guarda G, Zenger M, Yazdi AS, Schroder K, Ferrero I, Menu P, Tardivel A, Mattmann C, Tschopp J (2011).
Differential expression of NLRP3 among hematopoietic cells. Journal of Immunology 186: 2529-2534. Pubmed

 

32. van Zuylen WJ, Garceau V, Idris A, Schroder K, Irvine KM, Lattin JE, Ovchinnikov DA, Perkins AC, Cook AD, Hamilton JA, Hertzog PJ, Stacey KJ, Kellie S, Hume DA, Sweet MJ (2011).
Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis. PLoS One 6 e15723. Pubmed

 

31. Kawaji H, Severin J, Lizio M, Forrest AR, van Nimwegen E, Rehli M, Schroder K, Irvine K, Suzuki H, Carninci P, Hayashizaki Y, Daub CO (2011).
Update of the FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Research 39: D856-860. Pubmed

 

30. Low PC, Misaki R, Schroder K, Stanley AC, Sweet MJ, Teasdale RD, Vanhaesebroeck B, Meunier FA, Taguchi T, Stow JL (2010).
Phosphoinositide 3-kinase delta regulates membrane fission of Golgi carriers for selective cytokine secretion. Journal of Cell Biology 190: 1053-1065. Pubmed

 

29. Kubosaki A, Lindgren G, Tagami M, Simon C, Tomaru Y, Miura H, Suzuki T, Arner E, Forrest AR, Irvine KM, Schroder K, Hasegawa Y, Kanamori-Katayama M, Rehli M, Hume DA, Kawai J, Suzuki M, Suzuki H, Hayashizaki Y (2010).
The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells. Molecular Immunology 47: 2295-2302. Pubmed

 

28. Halili MA, Andrews MR, Labzin LI, Schroder K, Matthias G, Cao C, Lovelace E, Reid RC, Le GT, Hume DA, Irvine KM, Matthias P, Fairlie DP, Sweet MJ (2010).
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology 87: 1103-1114. Pubmed

 

27. Schroder K, Tschopp J (2010).
The inflammasomes. Cell 140: 821-832. Pubmed

 

26. Schroder K, Zhou R, Tschopp J (2010).
The NLRP3 inflammasome: a sensor for metabolic danger? Science 327: 296-300. Pubmed

 

25. Tschopp J, Schroder K (2010).
NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nature Reviews Immunology 10: 210-215. Pubmed

 

24. Hume DA, Schroder K, Irvine K (2010).
The impact of CAGE data on the understanding of macrophage transcriptional biology. Chapter 17 in Cap-Analysis Gene Expression (CAGE) - the Science of Decoding Genes Transcription, P. Carninci (Editor). (Singapore: Pan Stanford Publishing). Pan Stanford Publishing

 

23. Taft RJ, Glazov EA, Cloonan N, Simons C, Stephen S, Faulkner GJ, Lassmann T, Forrest AR, Grimmond SM, Schroder K, Irvine K, Arakawa T, Nakamura M, Kubosaki A, Hayashida K, Kawazu C, Murata M, Nishiyori H, Fukuda S, Kawai J, Daub CO, Hume DA, Suzuki H, Orlando V, Carninci P, Hayashizaki Y, Mattick JS (2009).
Tiny RNAs associated with transcription start sites in animals. Nature Genetics 41: 572-578. Pubmed

 

22. Faulkner GJ, Kimura Y, Daub CO, Wani S, Plessy C, Irvine KM, Schroder K, Cloonan N, Steptoe AL, Lassmann T, Waki K, Hornig N, Arakawa T, Takahashi H, Kawai J, Forrest AR, Suzuki H, Hayashizaki Y, Hume DA, Orlando V, Grimmond SM, Carninci P (2009).
The regulated retrotransposon transcriptome of mammalian cells. Nature Genetics 41: 563-571. Pubmed

 

21. FANTOM4 International Consortium: Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Bjorkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engstrom PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, Grimmond SM, Gustafsson M, Hashimoto M, Hashimoto T, Hatakeyama M, Heinzel S, Hide W, Hofmann O, Hornquist M, Huminiecki L, Ikeo K, Imamoto N, Inoue S, Inoue Y, Ishihara R, Iwayanagi T, Jacobsen A, Kaur M, Kawaji H, Kerr MC, Kimura R, Kimura S, Kimura Y, Kitano H, Koga H, Kojima T, Kondo S, Konno T, Krogh A, Kruger A, Kumar A, Lenhard B, Lennartsson A, Lindow M, Lizio M, Macpherson C, Maeda N, Maher CA, Maqungo M, Mar J, Matigian NA, Matsuda H, Mattick JS, Meier S, Miyamoto S, Miyamoto-Sato E, Nakabayashi K, Nakachi Y, Nakano M, Nygaard S, Okayama T, Okazaki Y, Okuda-Yabukami H, Orlando V, Otomo J, Pachkov M, Petrovsky N, Plessy C, Quackenbush J, Radovanovic A, Rehli M, Saito R, Sandelin A, Schmeier S, Schonbach C, Schwartz AS, Semple CA, Sera M, Severin J, Shirahige K, Simons C, St Laurent G, Suzuki M, Suzuki T, Sweet MJ, Taft RJ, Takeda S, Takenaka Y, Tan K, Taylor MS, Teasdale RD, Tegner J, Teichmann S, Valen E, Wahlestedt C, Waki K, Waterhouse A, Wells CA, Winther O, Wu L, Yamaguchi K, Yanagawa H, Yasuda J, Zavolan M, Hume DA, Arakawa T, Fukuda S, Imamura K, Kai C, Kaiho A, Kawashima T, Kawazu C, Kitazume Y, Kojima M, Miura H, Murakami K, Murata M, Ninomiya N, Nishiyori H, Noma S, Ogawa C, Sano T, Simon C, Tagami M, Takahashi Y, Kawai J, Hayashizaki Y (2009).
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics 41: 553-562. Pubmed

 

20. Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J (2009).
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Reports 10: 916-922. Pubmed

 

19. Mar JC, Kimura Y, Schroder K, Irvine KM, Hayashizaki Y, Suzuki H, Hume D, Quackenbush J (2009).
Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics 10: 110. Pubmed

 

18. Irvine KM, Andrews MR, Fernandez-Rojo MA, Schroder K, Burns CJ, Su S, Wilks AF, Parton RG, Hume DA, Sweet MJ (2009).
Colony-stimulating factor-1 (CSF-1) delivers a proatherogenic signal to human macrophages. Journal of Leukocyte Biology 85: 278-288. Pubmed

 

17. Schroder K, Muruve DA, Tschopp J (2009).
Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. Current Biology 19: R262-265. Pubmed

 

16. Wells CA, Salvage-Jones JA, Li X, Hitchens K, Butcher S, Murray RZ, Beckhouse AG, Lo YL, Manzanero S, Cobbold C, Schroder K, Ma B, Orr S, Stewart L, Lebus D, Sobieszczuk P, Hume DA, Stow J, Blanchard H, Ashman RB (2008).
The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. Journal of Immunology 180: 7404-7413. Pubmed

 

15. Maeda N, Nishiyori H, Nakamura M, Kawazu C, Murata M, Sano H, Hayashida K, Fukuda S, Tagami M, Hasegawa A, Murakami K, Schroder K, Irvine K, Hume D, Hayashizaki Y, Carninci P, Suzuki H (2008).
Development of a DNA barcode tagging method for monitoring dynamic changes in gene expression by using an ultra high-throughput sequencer. Biotechniques 45: 95-97. Pubmed

 

14. Lattin JE, Schroder K, Su AI, Walker JR, Zhang J, Wiltshire T, Saijo K, Glass CK, Hume DA, Kellie S, Sweet MJ (2008).
Expression analysis of G Protein-Coupled Receptors in mouse macrophages. Immunome Research 4: 5. Pubmed

 

13. Faulkner GJ, Forrest AR, Chalk AM, Schroder K, Hayashizaki Y, Carninci P, Hume DA, Grimmond SM (2008).
A rescue strategy for multimapping short sequence tags refines surveys of transcriptional activity by CAGE. Genomics 91: 281-288. Pubmed

 

12. Chang MK, Raggatt LJ, Alexander KA, Kuliwaba JS, Fazzalari NL, Schroder K, Maylin ER, Ripoll VM, Hume DA, Pettit AR (2008).
Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. Journal of Immunology 181: 1232-1244. Pubmed

 

11. Schroder K, Spille M, Pilz A, Lattin J, Bode KA, Irvine KM, Burrows AD, Ravasi T, Weighardt H, Stacey KJ, Decker T, Hume DA, Dalpke AH, Sweet MJ (2007).
Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages. Journal of Immunology 179: 3495-3503. Pubmed

 

10. Schroder K, Lichtinger M, Irvine KM, Brion K, Trieu A, Ross IL, Ravasi T, Stacey KJ, Rehli M, Hume DA, Sweet MJ (2007).
PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages. Journal of Leukocyte Biology 81: 1577-1590. Pubmed

 

9. Bode KA, Schroder K, Hume DA, Ravasi T, Heeg K, Sweet MJ, Dalpke AH (2007).
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology 122: 596-606. Pubmed

 

8. Lattin J, Zidar DA, Schroder K, Kellie S, Hume DA, Sweet MJ (2007).
G-protein-coupled receptor expression, function, and signaling in macrophages. Journal of Leukocyte Biology 82: 16-32. Pubmed

 

7. Wells CA, Chalk AM, Forrest A, Taylor D, Waddell N, Schroder K, Himes SR, Faulkner G, Lo S, Kasukawa T, Kawaji H, Kai C, Kawai J, Katayama S, Carninci P, Hayashizaki Y, Hume DA, Grimmond SM (2006).
Alternate transcription of the Toll-like receptor signaling cascade. Genome Biology 7: R10. Pubmed

 

6. Aung HT1, Schroder K1, Himes SR, Brion K, van Zuylen W, Trieu A, Suzuki H, Hayashizaki Y, Hume DA, Sweet MJ, Ravasi T (2006).
LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB Journal 20: 1315-1327. 1Joint contribution  Pubmed

 

5. Schroder K, Sweet MJ, Hume DA (2006).
Signal integration between IFNgamma and TLR signalling pathways in macrophages. Immunobiology 211: 511-524. Pubmed

 

4. Sester DP, Trieu A, Brion K, Schroder K, Ravasi T, Robinson JA, McDonald RC, Ripoll V, Wells CA, Suzuki H, Hayashizaki Y, Stacey KJ, Hume DA, Sweet MJ (2005).
LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology 210: 97-107. Pubmed

 

3. Ravasi T, Hsu K, Goyette J, Schroder K, Yang Z, Rahimi F, Miranda LP, Alewood PF, Hume DA, Geczy C (2004).
Probing the S100 protein family through genomic and functional analysis. Genomics 84, 10-22. Pubmed

 

2. Schroder K, Hertzog PJ, Ravasi T, Hume DA (2004).
Interferon-gamma: an overview of signals, mechanisms and functions. Journal of Leukocyte Biology 75, 163-189. Pubmed

 

1. Leung D, Schroder K, White H, Fang NX, Stoermer MJ, Abbenante G, Martin JL, Young PR, Fairlie DP (2001).
Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors. Journal of Biological Chemistry 276, 45762-45771. Pubmed

 

 

 

2. O'Neill LA, Coll RC, Cooper MA, Robertson AAB, Schroder K. MacLeod AM, Miller DJ (2017).
Sulfonylureas and related compounds and use of same. PCT/EP2017/053498, Filing: 16/02/2017.

 

1. O'Neill LA, Coll RC, Cooper MA, Robertson AAB, Schroder K (2016).
Sulfonylureas and related compounds and use of same. PCT/AU2016/050103, Filing: 16/02/2016.