Noncanonical inflammasome signalling animation: pyroptosis and NETosis in host defence

The Inflammasome Lab have discovered a new pathway for host defence against cytosolic Gram-negative bacteria, revealing unexpected links between pyroptosis and NETosis. We describe this new pathway of neutrophil host defence, alongside the related macrophage pyroptosis pathway, in this animated film.

 

Animated film - Noncanonical inflammasomes: signalling, pyroptosis and NETosis in host defence

Associate Professor Kate Schroder explains the signal transduction and host defence pathway of noncanonical inflammasomes — molecular machines that drive unusual forms of cell death called pyroptosis, and neutrophil death by extrusion of neutrophil extracellular traps (NETs, NETosis).

© 2018 The University of Queensland.  This film may be reproduced and communicated to the public (in whole or in part) for non-commercial research, education or study purposes only, provided all copyright and attribution notices appear in the copied or communicated film.  Subject to exceptions mandated by law, this film many not otherwise be reproduced or communicated to the public without the written permission of The University of Queensland.

For commercial use of this film, please contact Kate Schroder (K.Schroder@uq.edu.au). 

 

Chen KW1, Monteleone M1, Boucher D1, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K. (2018).
Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps. Science Immunology Aug 24;3(26). pii: eaar6676. Pubmed
1Equal contribution

 

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ABOUT Inflammasome Lab

Inflammasome Lab is a group of researchers led by Dr Kate Schroder at the Institute for Molecular Bioscience, The University of Queensland.
We seek to unravel the secrets of inflammasomes – protein complexes at the heart of inflammation and disease – to allow for new therapies to fight human diseases.