Caspase Activation and Cellular Programs

Project Description

Inflammasomes activate caspase family proteases, and thereby trigger caspase-dependent cellular programs, such as cytokine maturation and secretion, pyroptotic cell death and apoptotic cell death. We aim to understand precisely how inflammasomes control the activity of inflammatory caspases, and the proteolytic cascades that control cellular programs such as pyroptotic cell death and unconventional protein secretion.

 

Projects:

  • Mechanisms of inflammatory caspase activation
  • Caspase-1-dependent unconventional protein secretion

 

Select Publications:

  1. Baker PJ1, Boucher D1, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K2, Masters SL2 (2015).
    NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology 45:2918-26. 1, 2Joint Contribution. Pubmed
     
  2. Monteleone M, Stow JL, & Schroder K (2015).
    Mechanisms of unconventional secretion of IL-1 family cytokines. Cytokine 74(2):213-218. Pubmed
     
  3. Boucher D, Chen KW, & Schroder K (2015).
    Burn the house, save the day: pyroptosis in pathogen restriction. Inflammasome 2(1):1-6. Inflammasome
     
  4. Chen KW, Gross CJ, Sotomayor FV, Stacey KJ, Tschopp J, Sweet MJ, & Schroder K (2014).
    The neutrophil NLRC4 inflammasome selectively promotes IL-1beta maturation without pyroptosis during acute Salmonella challenge. Cell Reports 8(2):570-582. Pubmed
     
  5. Sagulenko V, Thygesen SJ, Sester DP, Idris A, Cridland JA, Vajjhala PR, Roberts TL, Schroder K, Vince JE, Hill JM, Silke J, & Stacey KJ (2013).
    AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death and Differentiation 20(9):1149-1160. Pubmed
     
  6. Schroder K & Tschopp J (2010).
    The inflammasomes. Cell 140(6):821-832. Pubmed

 

Image: Three-dimensional protein structures of the Caspase1 dimer. Image credit: Image generated in pymol by Dr Dave Boucher, using the 1ICE structure from the Protein Data Bank.

Categories: 
Cell biology
Molecular biology