Damiën Bierschenk


Damiën Bierschenk


PhD Candidate, Inflammasome Lab



Damiën obtained his Bachelor degree in life sciences in 2011 at the University of Applied Sciences in Rotterdam, the Netherlands. After receiving his degree he worked as a research assistant in the lab of Willem van Schaik at the University Medical Center Utrecht, the Netherlands. During this time Damiën co-authored various papers revolving around functional genomics of the gut pathogen Enterococcus faecium. He left the van Schaik lab to pursue a Masters degree in Biomedicine at the Karolinska institute in Stockholm, Sweden with a focus on immunology and microbiology. After receiving his Masters, Damiën joined the Inflammasome lab in October 2014 as a PhD candidate where he works on the activation of the inflammasome pathway by Salmonella.


The more difficult the victory, the greater the happiness in winning.




Email: d.bierschenk@imb.uq.edu.au

Office Telephone: +61 7 3346 2356

Lab Telephone: +61 7 3346 2071


Institute for Molecular Bioscience







2014   International Postgraduate Research Scholarship, The University of Queensland


2014   Centennial Scholarship, The University of Queensland




2014    Master in Biomedicine, Karolinska Institute, Stockholm, Sweden


2011    Bachelor in Life sciences, University of Applied Sciences, Rotterdam, The Netherlands



Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS and Schroder K. (2018).
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine In press. Pubmed
1Equal contribution

See Journal of Experimental Medicine for a complete list of citations, reviews and media attention this publication has recieved. Read the news articles here

Reseach Highlight:
Defusing inflammasomes. Sandstrom A, Vance RE. Journal of Experimental Medicine. Pubmed


Bierschenk D, Boucher D, Schroder K. (2017).
Salmonella-induced inflammasome activation in humans. Molecular Immunology Jun;86:38-43. Pubmed


Baker PJ1, Boucher D1, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K2, Masters SL2 (2015).
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology 45:2918-26. 1, 2Joint Contribution. Pubmed

Comment in:
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. European Journal of Immunology




Guzmán Prieto AM, Urbanus RT, Zhang X, Bierschenk D, Koekman CA, van Luit-Asbroek M, Ouwerkerk JP, Pape M, Paganelli FL, Wobser D, Huebner J, Hendrickx AP, Bonten MJ, Willems RJ, van Schaik W (2015).
The N-terminal domain of the thermo-regulated surface protein PrpA of Enterococcus faecium binds to fibrinogen, fibronectin and platelets. Scientific Reports 5:18255. Pubmed


Bollampalli VP, Harumi Yamashiro L, Feng X, Bierschenk D, Gao Y, Blom H, Henriques-Normark B, Nylén S, Rothfuchs AG (2015).
BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming. PLoS Pathogens 11(10):e1005206. Pubmed


Zhang X, Rogers M, Bierschenk D, Bonten MJ, Willems RJ, van Schaik W (2013).
A LacI-family regulator activates maltodextrin metabolism of Enterococcus faecium. PLoS One 8(8):e72285. Pubmed


Zhang X, Bierschenk D, Top J, Anastasiou I, Bonten MJ, Willems RJ, van Schaik W (2013).
Functional genomic analysis of bile salt resistance in Enterococcus faecium. BMC Genomics 14:299. Pubmed


Zhang X, Top J, de Been M, Bierschenk D, Rogers M, Leendertse M, Bonten MJ, van der Poll T, Willems RJ, van Schaik W (2013).
Identification of a genetic determinant in clinical Enterococcus faecium strains that contributes to intestinal colonization during antibiotic treatment. Journal of Infectious Diseases 207(11):1780-6. Pubmed


Zhang X, Paganelli FL, Bierschenk D, Kuipers A, Bonten MJ, Willems RJ, van Schaik W (2012).
Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium. PLoS Genetics 8(6):e1002804. Pubmed


Spuesens EB, Meijer A, Bierschenk D, Hoogenboezem T, Donker GA, Hartwig NG, Koopmans MP, Vink C, van Rossum AM (2012).
Macrolide resistance determination and molecular typing of Mycoplasma pneumoniae in respiratory specimens collected between 1997 and 2008 in The Netherlands. Journal of Clinical Microbiology. 50(6):1999-2004. Pubmed