Dave has a particular crush on caspases, a very appealing family of proteases. He is inspired by good science and excited about making discoveries. He enjoys a good chat about exciting hypotheses and papers pitfalls around a good coffee (or a tasty beer).
Telephone: +61 7 3346 2356
AWARDS, GRANTS AND PRIZES
2015-2018 Postdoctoral Fellowship, The University of Queensland
2015 Ian Potter Travel Grant
2013-2015 Postdoctoral Fellowship, Fonds de Recherche du Québec en Santé
2013 Dean Honors List, University of Sherbrooke
2012 Best Poster award (external program), Research Day of the Faculty of Pharmacy, Laval University
2011 Dean Honors List, University of Sherbrooke
2011 Travel award, International Proteolysis Society meeting
2007 Sherbrooke institutional scholarship, University of Sherbrooke
2012 PhD in Pharmacology, University of Sherbrooke, Sherbrooke, Canada (Research)
2009 Masters Degree in Pharmacology, University of Sherbrooke (Research, fast track to PhD)
2007 Bachelor Degree in Biotechnology, University of Sherbrooke (Molecular Biology)
7 February 2018, Scientists discover off-switch for ‘molecular machine’ active in many diseases, UQ News
Dave Boucher from the Inflammasome Lab discovered that inflammasomes normally function with an in-built timer switch, that ensures that their activation of the inflammation process is eventually switched off.
UQ News article
This discovery featured in 16 international news articles and 2 TV news stories including those in: Health Medicine Network, The Medical News, SciCasts, Zee News, Yahoo! News, Business Standard, My Science, Science Newsline, EurekAlert!, and more. Read the news articles here.
See Journal of Experimental Medicine for a complete list of citations, reviews and media attention this publication has recieved.
21 December 2017, IMB staff and students make an impact
The IMB's annual impact awards recognise those within the Institute who inspire and enable others to achieve their potential through teamwork, service, innovation and leadership. Dave Boucher received a special commendation in the Leadership category.
12 November 2014, Young researchers awarded UQ fellowships
Three talented young researchers awarded UQ postdoctoral fellowships to support their promising research. Young immunologist Dr Dave Boucher will use his fellowship to unlock the secrets of the inflammasome – a cluster of molecules that trigger inflammation in the body. His research, performed in Dr Kate Schroder’s lab, will help us to understand how inflammasome dysfunction can contribute to chronic inflammatory disease.
Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS and Schroder K. (2018).
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine In press. Pubmed
Defusing inflammasomes. Sandstrom A, Vance RE. Journal of Experimental Medicine. Pubmed
Boucher D, Chan A, Ross C, Schroder K. (2018).
Quantifying Caspase-1 Activity in Murine Macrophages. Methods in Molecular Biology 1725:163-176. Pubmed
Bierschenk D, Boucher D, Schroder K. (2017).
Salmonella-induced inflammasome activation in humans. Molecular Immunology Jun;86:38-43. Pubmed
Baker PJ1, Boucher D1, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K2, Masters SL2 (2015).
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology 45:2918-26. 1, 2Joint Contribution. Pubmed
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. European Journal of Immunology
Boucher DB, Chen KW, Schroder K (2015).
Burn the house, save the day: pyroptosis in pathogen restriction. Inflammasome 2: 1-6. Inflammasome
Desroches A, Boucher D, Denault J-B (2016).
Caspases. Encyclopedia of Signaling Molecules (Book chapter, DOI 10.1007/978-1-4614-6438-9_176-1)
Boucher D, Denault J-B (2014).
General in vitro assay caspase procedure. Methods in Molecular Biology 1133:3-39.
Boucher D, Blais V, Denault J-B (2012).
Caspase-7 uses an exosite to promote poly (ADP ribose) polymerase 1 proteolysis. Proceedings of the National Academy of Science U S A Apr 10; 109(15):5669-74.
Boucher D, Blais V, Denault J-B (2010).
Molecular determinants involved in caspase-7 activation. Bioscience Reports Mar 2; 31(4):283-94.
Boucher D and Denault J.-B (2012).
Caspases. Encyclopedia of Signaling Molecules (Book chapter, DOI 10.1007/978-1-4419-0461-4)
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