Dave Boucher


Dr Dave Boucher


PostDoctoral Researcher, Inflammasome Lab
PostDoctoral Fellow, The University of Queensland



Dave Boucher obtained his PhD in Pharmacology from the University of Sherbrooke (Sherbrooke, QC, Canada) and after a short PostDoc in San Diego (CA, USA), joined Dr Kate Schroder’s group in 2014. His research focuses on how proteases are involved in immune and cell death signalling in health and disease. He is interested in understanding how proteases are activated, how they recognize particular substrates and how substrate proteolysis influences specific signalling pathways. Ultimately, Dave would like to use this knowledge to develop new pharmacological drugs.


Dave has a particular crush on caspases, a very appealing family of proteases. He is inspired by good science and excited about making discoveries. He enjoys a good chat about exciting hypotheses and papers pitfalls around a good coffee (or a tasty beer).




Email: d.boucher@imb.uq.edu.au

Telephone: +61 7 3346 2356


Institute for Molecular Bioscience

The University of Queensland, UQ Researcher

Research Gate







2015-2018 Postdoctoral Fellowship, The University of Queensland


2015 Ian Potter Travel Grant


2013-2015 Postdoctoral Fellowship, Fonds de Recherche du Québec en Santé


2013 Dean Honors List, University of Sherbrooke


2012 Best Poster award (external program), Research Day of the Faculty of Pharmacy, Laval University


2011 Dean Honors List, University of Sherbrooke


2011 Travel award, International Proteolysis Society meeting


2007 Sherbrooke institutional scholarship, University of Sherbrooke





2012  PhD in Pharmacology, University of Sherbrooke, Sherbrooke, Canada (Research)


2009  Masters Degree in Pharmacology, University of Sherbrooke (Research, fast track to PhD)


2007  Bachelor Degree in Biotechnology, University of Sherbrooke (Molecular Biology)



7 February 2018, Scientists discover off-switch for ‘molecular machine’ active in many diseases, UQ News
Dave Boucher from the Inflammasome Lab discovered that inflammasomes normally function with an in-built timer switch, that ensures that their activation of the inflammation process is eventually switched off.
UQ News article

This discovery featured in 16 international news articles and 2 TV news stories including those in: Health Medicine Network, The Medical News, SciCasts, Zee News, Yahoo! News, Business Standard, My Science, Science Newsline, EurekAlert!, and more. Read the news articles here.
See Journal of Experimental Medicine for a complete list of citations, reviews and media attention this publication has recieved.


21 December 2017, IMB staff and students make an impact

The IMB's annual impact awards recognise those within the Institute who inspire and enable others to achieve their potential through teamwork, service, innovation and leadership. Dave Boucher received a special commendation in the Leadership category.

Read the full IMB news article


12 November 2014, Young researchers awarded UQ fellowships

Three talented young researchers awarded UQ postdoctoral fellowships to support their promising research. Young immunologist Dr Dave Boucher will use his fellowship to unlock the secrets of the inflammasome – a cluster of molecules that trigger inflammation in the body. His research, performed in Dr Kate Schroder’s lab, will help us to understand how inflammasome dysfunction can contribute to chronic inflammatory disease.

Read the full IMB news article



Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS and Schroder K. (2018).
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine In press. Pubmed
1Equal contribution

See Journal of Experimental Medicine for a complete list of citations, reviews and media attention this publication has recieved. Read the news articles here

Reseach Highlight:
Defusing inflammasomes. Sandstrom A, Vance RE. Journal of Experimental Medicine. Pubmed


Boucher D, Chan A, Ross C, Schroder K. (2018).
Quantifying Caspase-1 Activity in Murine Macrophages. Methods in Molecular Biology 1725:163-176. Pubmed


Bierschenk D, Boucher D, Schroder K. (2017).
Salmonella-induced inflammasome activation in humans. Molecular Immunology Jun;86:38-43. Pubmed


Baker PJ1, Boucher D1, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K2, Masters SL2 (2015).
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology 45:2918-26. 1, 2Joint Contribution. Pubmed

Comment in:
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. European Journal of Immunology


Boucher DB, Chen KW, Schroder K (2015).
Burn the house, save the day: pyroptosis in pathogen restriction. Inflammasome 2: 1-6. Inflammasome




Desroches A, Boucher D, Denault J-B (2016).
Caspases. Encyclopedia of Signaling Molecules (Book chapter, DOI 10.1007/978-1-4614-6438-9_176-1)


Boucher D, Denault J-B (2014).
General in vitro assay caspase procedure. Methods in Molecular Biology 1133:3-39.


Boucher D, Blais V, Denault J-B (2012).
Caspase-7 uses an exosite to promote poly (ADP ribose) polymerase 1 proteolysis. Proceedings of the National Academy of Science U S A Apr 10; 109(15):5669-74.


Boucher D, Blais V, Denault J-B (2010).
Molecular determinants involved in caspase-7 activation. Bioscience Reports Mar 2; 31(4):283-94.


Boucher D and Denault J.-B (2012).
Caspases. Encyclopedia of Signaling Molecules (Book chapter, DOI 10.1007/978-1-4419-0461-4)