Dave Boucher

 

Dr Dave Boucher

 

PostDoctoral Researcher, Inflammasome Lab
PostDoctoral Fellow, The University of Queensland

 

 

Dave Boucher obtained his PhD in Pharmacology from the University of Sherbrooke (Sherbrooke, QC, Canada) and after a short PostDoc in San Diego (CA, USA), joined Dr Kate Schroder’s group in 2014. His research focuses on how proteases are involved in immune and cell death signalling in health and disease. He is interested in understanding how proteases are activated, how they recognize particular substrates and how substrate proteolysis influences specific signalling pathways. Ultimately, Dave would like to use this knowledge to develop new pharmacological drugs.

 

Dave has a particular crush on caspases, a very appealing family of proteases. He is inspired by good science and excited about making discoveries. He enjoys a good chat about exciting hypotheses and papers pitfalls around a good coffee (or a tasty beer).

 

CONTACTS AND LINKS


 

Email: d.boucher@imb.uq.edu.au

Telephone: +61 7 3346 2356

 

Institute for Molecular Bioscience

The University of Queensland, UQ Researcher

Research Gate

 

AWARDS AND PUBLICATIONS


 

 

AWARDS, GRANTS AND PRIZES

 

2015-2018 Postdoctoral Fellowship, The University of Queensland

 

2015 Ian Potter Travel Grant

 

2013-2015 Postdoctoral Fellowship, Fonds de Recherche du Québec en Santé

 

2013 Dean Honors List, University of Sherbrooke

 

2012 Best Poster award (external program), Research Day of the Faculty of Pharmacy, Laval University

 

2011 Dean Honors List, University of Sherbrooke

 

2011 Travel award, International Proteolysis Society meeting

 

2007 Sherbrooke institutional scholarship, University of Sherbrooke

 

 

EDUCATION

 

2012  PhD in Pharmacology, University of Sherbrooke, Sherbrooke, Canada (Research)

 

2009  Masters Degree in Pharmacology, University of Sherbrooke (Research, fast track to PhD)

 

2007  Bachelor Degree in Biotechnology, University of Sherbrooke (Molecular Biology)

 

 

12 November 2014, Young researchers awarded UQ fellowships

Three talented young researchers awarded UQ postdoctoral fellowships to support their promising research. Young immunologist Dr Dave Boucher will use his fellowship to unlock the secrets of the inflammasome – a cluster of molecules that trigger inflammation in the body. His research, performed in Dr Kate Schroder’s lab, will help us to understand how inflammasome dysfunction can contribute to chronic inflammatory disease.

Read the full IMB news article

 

 

ORIGINAL RESEARCH ARTICLES

 

Baker PJ, Boucher D, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K, Masters SL (2015).
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology 45:2918-26. Pubmed
Comment in:
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways. European Journal of Immunology

 

REVIEWS, COMMENTARIES AND BOOK CHAPTERS

 

Bierschenk D, Boucher D, Schroder K. (2016).
Salmonella-induced inflammasome activation in humans. Molecular Immunology S0161-5890(16)30242-5. Pubmed

 

Boucher DB, Chen KW, Schroder K (2015).
Burn the house, save the day: pyroptosis in pathogen restriction. Inflammasome 2: 1-6. Inflammasome

 

 

ORIGINAL RESEARCH ARTICLES

 

Boucher D., Blais V., Denault J.-B. (2012). Caspase-7 uses an exosite to promote poly (ADP ribose) polymerase 1 proteolysis. Proc. Natl. Acad. Sci. U S A. 2012 Apr 10;109(15):5669-74.

 

Boucher D., Blais V., Drag M., Denault J.-B. (2010). Molecular determinants involved in caspase-7 activation. Bioscience Rep. Mar 2;31(4):283-94.

 

REVIEWS, COMMENTARIES AND BOOK CHAPTERS

 

Boucher D. and Denault J.-B (2014). General in vitro assay caspase procedure. Meth. Mol. Biol. 1133:3-39

 

Boucher D. and Denault J.-B (2012). Caspases. Encyclopedia of Signaling Molecules (Book chapter, DOI 10.1007/978-1-4419-0461-4)