Dr Larisa Labzin

 

Dr Larisa Labzin

 

 

PostDoctoral Researcher, Inflammasome Lab

 

 

 

Larisa’s interest in innate immunity began during her honours training with Prof. Matt Sweet at the IMB, where she looked at how TLR4 signalling is regulated by HDACs. After gaining more experience as a research assistant, Larisa moved to Germany to the University of Bonn for her PhD. At Bonn, she investigated the anti-inflammatory effects of High Density Lipoprotein with Prof. Eicke Latz. Larisa then moved to Cambridge, UK, for her postdoctoral training with Dr. Leo James to investigate how antibodies modulate macrophage sensing of adenovirus. Larisa will continue to investigate how viruses trigger inflammasome activation while in the Inflammasome Lab.

 

In theory, there is no difference between theory and practice. But, in practice, there is.”

Manfred Eigen

 

CONTACTS AND LINKS

 

Email: l.labzin@uq.edu.au

Office Telephone: + 61 7 3346 2076

Lab Telephone: +61 7 3346 2071

 

Institute for Molecular Bioscience

Google Scholar

 

AWARDS AND PUBLICATIONS

 

 

AWARDS, GRANTS AND PRIZES

 

2017 Research Excellence Award, Frank Fenner Early Career Fellowship Award, NHMRC, Australia.

 

2017 Postdoctoral Fellow Scholarship, CJ Martin Overseas Biomedical Fellowship, NHMRC, Australia.

 

2016 Postdoctoral Fellow Scholarship, EMBO Long Term Fellowship, Germany.

 

2016 Travel Award, Weizmann Institute of Science, to attend Next Gen Immunology 2016, Tel Aviv, Israel.

 

2015 Travel Award, the Maria von Linden Program, University of Bonn, to attend Toll 2015, Marbella, Spain.

 

2015 Prize for best poster presentation, Innate Immune Memory, Cambridge, UK.

 

2015 Travel Award, the Wellcome Trust Advanced Courses and Scientific Conferences, to attend Innate Immune Memory, Cambridge, UK.

 

2015 Travel Award, Deutsche Akademische Austausch Dienst (DAAD) - German Academic Exchange Service, to attend Cytokines, San Francisco, USA.

 

2013 Prize for best Oral Presentation, Cluster of Excellence Immunosensation, inaugural Cluster Science Day, Bonn, Germany.

 

EDUCATION

 

2015  Dr.rer.nat. (PhD), Molecular Biomedicine, Faculty of Mathematics and Natural Sciences, Rheinische Friedrich-Wilhelms University of Bonn, Germany. Grade: summa cum laude

 

2007  BSc Honors (Microbiology), Institute of Molecular Bioscience, University of Queensland, Australia.

 

2006  BA (German, International Relations), BSc (Biochemistry), University of Queensland, Australia.

 

 

Labzin LI, Bottermann M, Rodriguez-Silvestre P, Foss S, Andersen JT, Vaysburd M, Clift D, James LC. (2019).
Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal.  Epub ahead of print.

 

Castro-Dopico T, Dennison TW, Ferdinand JR, Mathews RJ, Fleming A, Clift D, Stewart BJ, Jing C, Strongili K, Labzin LI, Monk EJM, Saeb-Parsy K, Bryant CE, Clare S, Parkes M, Clatworthy MR.(2019).
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity Apr 16;50(4):1099-1114. Pubmed

 

Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M. (2017).
A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell Dec 14;171(7):1692-1706. Pubmed

 

Labzin LI, Henneka, M, Latz E. (2017).
Innate Immunity and Neurodegeneration. Annual Reviews of Medicine Feb 19;17(1):44. Pubmed

 

Labzin, L.I., Lauterbach, M.A. and Latz, E. (2016).
Interferons and inflammasomes: Cooperation and counterregulation in disease. The Journal of Immunology 1;199(11):3914-3924. Pubmed

 

Zimmer, S., Grebe, A., Bakke, S.S., Bode, N., Halvorsen, B., Ulas, T., Skjelland, M., De Nardo, D., Labzin, L.I., Kerksiek, A., Hempel, C., Heneka, M.T., Hawxhurst, V., Fitzgerald, M.L., Trebicka, J., Gustafsson, J., Westerterp, M., Tall, A.R., Wright, S.D., Espevik, T., Schultze, J.L., Nickenig, G., Lütjohann, D and Latz, E. (2016).
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine Apr 6;8(333):333ra50. Pubmed

 

Labzin, L. I., Schmidt, S. V., Masters, S. L., Beyer, M., Krebs, W., Klee, K., Stahl, R., Lütjohann, D., Schultze, J. L., Latz, E., De Nardo, D. (2015).
ATF3 is a key regulator of macrophage interferon-responses. Journal of Immunology Nov 1;195(9):4446-55. Pubmed

 

Krebs, W., Schmidt, S.V., Goren, A., De Nardo, D., Labzin, L., Bovier, A., Ulas, T., Theis, H., Kraut, M., Latz, E., Beyer, M. and Schultze, J. (2014).
Optimization of transcription factor binding map accuracy utilizing knockout-mouse models. Nucleic Acids Research Dec 1;42(21):13051-60. Pubmed

 

Pelka, K., Phulphagar, K., Zimmermann, J., Stahl, R., Schmid-Burgk, J.L., Schmidt, T., Spille, J.H., Labzin, L.I., Agrawal, S., Kandimalla, E.R., Casanova, J.L., Hornung, V., Marshak-Rothstein, A., Höning, S., Latz, E. (2014).
Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms. The Journal of Immunology Oct 1;193(7):3257-61. Pubmed

 

Xue, J., Schmidt, S.V., Sander, J., Draffehn, A., Krebs, W., Quester, I., de Nardo, D., Gohel, T.D., Emde, M., Schmidleithner, L., Ganesan, H., Nino-Castro, A., Mallmann, M.R., Labzin, L., Theis, H., Kraut, M., Beyer, M., Latz, E., Freeman, T.C., Ulas, T. and Schultze, J.L. (2014).
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity Feb 20;40(2):274-88. Pubmed

Selected for:
Faculty of 1000 highlight

 

Xde Nardo, D1., Labzin, L.I1., Kono, H., Seki, R., Schmidt, S.V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F.A., Vogelhuber, J., Kraut, M., Ulas, T., Kerksiek, A., Krebs, W., Bode, N., Grebe, A., Fitzgerald, M.L., Hernandez, N.J., Williams, B.R.G., Knolle, P., Kneilling, M., Röcken, M., Lütjohann, D., Wright, S.D., Schultze, J.L. and Latz, E. (2014).
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nature Immunology Feb;15(2):152-60. Pubmed
1Equal contribution

Highlighted in:
Old HDL learns a new (anti-inflammatory) trick. Odegaard, J. I. and Chawla, A., 2014 Nature Immunology. Highlighted in:
High Density Lipoproteins Put Out the Fire. Moore, K. J. and Fisher, E. A., 2014 Cell Metabolism. Highlighted in:
The anti-inflammatory effects of HDL through ATF3: benefit beyond cholesterol transport-dependent processes. Zhang, H.R. and Reilly, M.P. 2014 Nature.

Selected for:
Faculty of 1000 highlight

 

Shakespear, M.R., Hohenhaus, D.M., Kelly, G.M., Kamal, N.A., Gupta, P., Labzin, L.I., Schroder, K., Garceau, V., Barbero, S., Iyer, A., Hume, D.A., Reid, R.C., Irvine, K.M., Fairlie, D.P. and Sweet, M.J. (2013).
Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages. Journal of Biological Chemistry Aug 30;288(35):25362-74. Pubmed

 

Schroder, K., Irvine, K.M., Taylor, M.S., Bokil, N.J., Le Cao, K.A., Masterman, K. A., Labzin, L.I., Semple, C.A., Kapetanovic, R., Fairbairn, L., Akalin, A., Faulkner, G.J., Baillie, J.K., Gongora, M., Daub, C.O., Kawaji, H., McLachlan, G.J., Goldman, N., Grimmond, S.M., Carninci, P., Suzuki, H., Hayashizaki, Y., Lenhard, B., Hume, D.A. and Sweet, M.J. (2012).
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences Apr 17;109(16):E944-53. Pubmed

 

de Nardo, D., Vogelhuber, J., Labzin, L., Langhoff, P., and Latz, E. (2012).
Inflammasomopathies: Diseases Linked to the NLRP3 Inflammasome. New-Opathies, An Emerging Molecular Reclassification of Human Disease pp.23-65, Friedberg, E.C., Castrillon, D.H., Galindo, R.L., Wharton, K (Editors). (Singapore: World Scientific Publishing Company) World Scientific Publishing Company

 

Christ, A.N1., Labzin, L1., Bourne, G.T., Fukunishi, H., Weber, J.E., Sweet, M.J., Smythe, M.L., and Flanagan, J.U. (2010).
Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases. Journal of Medicinal Chemistry Aug 12;53(15):5536-48. Pubmed
1Equal contribution

 

Halili, M.A., Andrews, M.R., Labzin, L.I., Schroder, K., Matthias, G., Cao, C., Lovelace, E., Reid, R.C., Le, G.T., Hume, D.A., Irvine, K.M., Matthias, P., Fairlie, D.P. and Sweet, M.J. (2010).
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology Jun;87(6):1103-14. Pubmed