Dr Madhavi Maddugoda
Dr Madhavi (Madi) Maddugoda
Science Writer, Illustrator and Editor, Inflammasome Lab
Madi obtained her PhD in cell biology at the Institute for Molecular Bioscience in 2008, before heading to France as an ARC young researcher fellow. Working at INSERM C3M institute in Nice, Madi studied the interplay between cell biology, microbiology and physics during Staphylococcus aureus invasion through endothelial cellular tunnels. Returning to Sydney, Australia, Madi put her hand to the delicate art of adult stem cell differentiation as part of a large consortium study looking into epigenetic programming of adipocytes in diabetes and obesity. Having conducted research in a range of scientific fields, Madi has now turned her attention to communicating scientific research and ideas using words and visuals. At the inflammasome lab Madi works part-time helping to craft grants, publications and the Inflammasome Lab website.
"To make an end is to make a beginning”
T S Eliot
CONTACTS AND LINKS
Email: m.maddugoda@imb.uq.edu.au
Office Telephone: +61 7 3346 2351
Institute for Molecular Bioscience
AWARDS AND PUBLICATIONS
AWARDS
2018 Cover image for Genome Research May 2018 edition Genome Research Cover
2009 Young researcher fellowship ARC (L’Association pour la Recherche sur le Cancer), France
2007 Young scientist travel award, American Society for Cell Biology (ASCB), USA
2006 Travel award, Queensland Cancer Fund, Australia
2004 Dora Lush PhD scholarship, National Health and Medical Research Council (NHMRC), Australia
2001 Dean’s commendation for high achievements, The University of Queensland, Australia
2000 Dean’s commendation for high achievements, The University of Queensland, Australia
2000 Department commendation for high achievements, The University of Queensland, Australia
EDUCATION
2007 PhD (Cell Biology), The University of Queensland, Australia
2002 Honours 1st Class, The University of Queensland, Australia
2001 BSc, The University of Queensland, Australia
Stephen T Bradford, Shalima S Nair, Aaron L Statham, Susan J van Dijk, Timothy J Peters, Firoz Anwar, Hugh J French, Julius ZH von Martels, Brodie Sutcliffe, Madhavi P Maddugoda, Michelle Peranec, Hilal Varinli, Rosanna Arnoldy, Michael Buckley, Jason P Ross, Elena Zotenko, Jenny Z Song, Clare Stirzaker, Denis C Bauer, Wenjia Qu, Michael M Swarbrick, Helen L Lutgers, Reginald V Lord, Katherine Samaras, Peter L Molloy, Susan J Clark (2019).
Methylome and transcriptome maps of human visceral and subcutaneous adipocytes reveal key epigenetic differences at developmental genes. Scientific reports Jul 2;9(1):9511. Pubmed
Giles KA, Gould CM, Du Q, Skvortsova K, Song JZ, Maddugoda MP, Achinger-Kawecka J, Stirzaker C, Clark SJ, Taberlay PC (2019).
Integrated epigenomic analysis stratifies chromatin remodellers into distinct functional groups. Epigenetics Chromatin Feb 12;12(1):12. Pubmed
Nair SS, Luu PL, Qu W, Maddugoda M, Huschtscha L, Reddel R, Chenevix-Trench G, Toso M, Kench JG, Horvath LG, Hayes VM, Stricker PD, Hughes TP, White DL, Rasko JEJ, Wong JJ, Clark SJ (2018).
Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten. Epigenetics Chromatin May 28;11(1):24. Pubmed
Stefani C, Gonzalez-Rodriguez D, Senju Y, Doye A, Efimova N, Janel S, Lipuma J, Tsai MC, Hamaoui D, Maddugoda MP, Cochet-Escartin O, Prévost C, Lafont F, Svitkina T, Lappalainen P, Bassereau P, Lemichez E (2017).
Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation. Nature Communications Jun 23;8:15839. Pubmed
David Gonzalez-Rodriguez1, Madhavi P. Maddugoda1, Caroline Stefani, Sebastien Janel, Frank Lafont, Damien Cuvelier, Emmanuel Lemichez, and Francoise Brochard-Wyart (2012).
Cellular Dewetting: Opening of Macroapertures in Endothelial Cells. Physical Review Letters May 25;108(21), 218105 (5 pages). Pubmed
1Equal contribution
Maddugoda MP1, Stefani C1, Gonzalez-Rodriguez D, Saarikangas J, Torrino S, Janel S, Munro P, Doye A, Prodon F, Aurrand-Lions M, Goossens PL, Lafont F, Bassereau P, Lappalainen P, Brochard F, Lemichez E (2011).
cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization. Cell Host Microbe Nov 17;10(5):464-74. Pubmed
1Equal contribution
Highlighted as:
Editors choice (2011) Science Dec 23;334:1650
Michel G, Ferrua B, Lang T, Maddugoda MP, Munro P, Pomares C, Lemichez E, Marty P (2011).
Luciferase-expressing Leishmania infantum allows the monitoring of amastigote population size, in vivo, ex vivo and in vitro. PLoS Neglected Tropical Diseases Sep;5(9):e1323. Pubmed
Visvikis O, Maddugoda MP, Lemichez (2010).
Direct modifications of Rho proteins: deconstructing GTPase regulation.Biology of the Cell Apr 6;102(7):377-89. Pubmed
den Elzen N, Buttery CV, Maddugoda MP, Ren G, Yap AS (2009).
Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia. Molecular Biology of the Cell Aug;20(16):3740-50. Pubmed
Bradford ST, Hiramatsu R, Maddugoda MP, Bernard P, Chaboissier MC, Sinclair A, Schedl A, Harley V, Kanai Y, Koopman P, Wilhelm D (2009).
The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice. Biology of Reproduction Jun;80(6):1178-88. Pubmed
Maddugoda MP, Crampton MS, Shewan AM, Yap AS (2007).
Myosin VI and vinculin cooperate during the Morphogenesis of cadherin cell-cell contacts in mammalian epithelial cells. Journal of Cell Biology Jul;178 (3): 529-40. Pubmed
Highlighted as Research Dispatched:
Breshears LM, Titus MA (2007).
Motor Proteins: tightening your belt with myosin VI. Current Biology Nov 6;17(21):R915-7 Pubmed
Shewan AM, Maddugoda M, Kraemer A, Stehbens SJ, Verma S, Kovacs EM, Yap AS (2005)
Myosin 2 is a key Rho kinase target necessary for the local concentration of E-cadherin at cell-cell contacts. Molecular Biology of the Cell Oct;16(10):4531-42. Pubmed
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