Innate immune cells sense cellular ‘danger’ through a broad repertoire of innate immune receptors, such as Nod-like receptors and Toll-like receptors (TLRs). These signalling systems are interconnected through multiple layers of signal cross-talk. Our research aims to understand the mechanisms by which TLR and cytokine signalling pathways influence the assembly of inflammasomes and their downstream signalling pathways.
Image: Artwork represents inflammasomes inside the cell and Toll-like Receptors on the cell membrane.
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