Inflammasomes in Disease

Project Description

Inflammasome dysregulation drives pathology in a wide variety of human diseases (e.g. septic shock, gout, diabetes, neurodegenerative diseases, various cancers). We seek to understand the mechanisms by which inflammasomes drive human diseases, and use this knowledge to develop new inflammasome inhibitors.

 

Projects:

  • Pathological inflammasome functions in diabetes
  • Genetic determinants of human inflammatory diseases
  • New drugs to treat human inflammasome-driven diseases

 

Select Publications:

  1. Coll RC, Robertson AAB, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KHG, Masters SL, Schroder K, Cooper MA, O’Neill LAJ (2015).
    A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine 21(3):248-55. Pubmed
     
  2. Sester DP, Thygesen SJ, Sagulenko V, Vajjhala PR, Cridland JA, Vitak N, Chen KW, Osborne GW, Schroder K, Stacey KJ (2015).
    A novel flow cytometric method to assess inflammasome formation. Journal of Immunology 194(1):455-462. Pubmed
     
  3. Zeis T, Allaman I, Gentner M, Schroder K, Tschopp J, Magistretti PJ, Schaeren-Wiemers N (2015).
    Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling. Brain, Behavior, Immunity 48:313-25. Pubmed
     
  4. Irvine KM, Schroder K, Powell EE (2012).
    Liver repercussions of defective gut surveillance. Hepatology 56: 1174-1177. Pubmed
     
  5. Schroder K, Zhou R, Tschopp J (2010).
    The NLRP3 inflammasome: a sensor for metabolic danger? Science 327: 296-300. Pubmed

 

Image: Artwork represents the role of inflammasomes in human disease. Diabetes is shown as an example.

Categories: 
Genetics
In vivo biology