Jelena Bezbradica Mirkovic

 

Dr Jelena Bezbradica Mirkovic

 

Research Officer, Inflammasome Lab
Kennedy Trust for Rheumatology Research (KTRR) Fellow, Oxford University

 

 

Jelena is an Early Career Researcher within the Inflammasome Lab. Jelena received her PhD in Immunology from the laboratory of Professor Sebastian Joyce at Vanderbilt University in the USA, and completed her postdoctoral training in Immunology in the laboratory of Professor Ruslan Medzhitov at Yale University, USA. Jelena joined the laboratory of Dr Kate Schroder as a Research Officer in 2014. She is currently focusing her research efforts towards understanding the biology of inflammatory responses to sterile versus microbe-induced tissue injury. Jelena will be starting her own research group at Oxford University, UK in 2016. But before that, she enjoys working with fun and creative people from the Inflammasome Lab!

 

CONTACTS AND LINKS


 

Email: j.bezbradica@imb.uq.edu.au

Office Telephone: +61 7 3346 2100

Laboratory Telephone: +61 7 3346 2356

 

Institute for Molecular Bioscience

The University of Queensland, UQ Researcher

Linkedin

 

AWARDS AND PUBLICATIONS


 

 

AWARDS, GRANTS AND PRIZES

 

2016-2021  Senior Research Fellowship, Kennedy Trust for Rheumatology Research (KTRR), Oxford University, UK

 

2016-2019  NHMRC Project Grant, serving as Chief Investigator B, with Dr Kate Schroder as Chief Investigator A, The University of Queensland, Australia

 

2014-2015  Early Career Researcher Grant, The University of Queensland, Australia

 

2008-2011  Damon Runyon Cancer Research Foundation (DRCRF) Fellowship, USA

 

2008-2011  Howard Hughes Medical Institute (HHMI) Fellowship (named HHMI Fellow of the Damon Runyon Cancer Research Foundation; of 31 Damon Runyon fellows in 2008, 4 were selected by HHMI for funding), USA

 

2008  Cancer Research Institute (CRI) Fellowship; fellowship declined upon acceptance of DRCRF/HHMI fellowship, USA

 

2006  Outstanding Graduate Student Award, Sidney P. Colowick, Vanderbilt University

 

EDUCATION

 

2003–2006  Doctor of Philosophy in Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA. Thesis title: “Lineage commitment and functional differentiation of invariant natural T (iNKT) cells”. Laboratory of Professor Sebastian Joyce.

 

1996–2003  Bachelor of Science, The Faculty of Pharmacy, Department of Medical Biochemistry, University of Belgrade, Belgrade, Serbia.

 

 

ORIGINAL RESEARCH ARTICLES

 

Bezbradica JS1, Coll R1, Schroder K (2016).
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals. Cellular & Molecular Immunology. In press. 1Joint contribution.

 

Chen KW, Bezbradica JS, Gross CJ, Wall AA, Sweet MJ, Stow JL, Schroder K (2016).
The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists. European Journal of Immunology In press.

 

REVIEWS, COMMENTARIES AND BOOK CHAPTERS

 

Bezbradica JS, Schroder K (2014).
TRAF6 is a nexus for TLR-STAT1 crosstalk. Immunology and Cell Biology 92: 737-738. Pubmed
Comment on:
STAT1 plays a role in TLR signal transduction and infammatory responses. Luu K et al 2014 Immunol Cell Biol.

 

 

Spencer, C.T., Bezbradica, J.S., Ramos, M.G., Arico, C.D., Conant, S.B., Gray, J.J., Zheng, M., Niu, N., Hildebrand, W., Link, A.J. and Joyce, S (2015).
Viral infection causes a shift in self peptide repertoire presented by human MHC class I molecule, Proteomics-Clinical Applications, 9: 1035-1052.

 

Bezbradica, J.S., Rosenstein, R.K., DeMarco, R.A., Brodsky, I., Medzhitov, R (2014).
A role for the ITAM signaling module in specifying cytokine-receptor functions, Nature Immunology, 15: 333-342

 

Rosenstein, R.K., Bezbradica, J.S., Yu, S., Medzhitov, R. (2014).
Innate Immune Signaling of Protease Allergens. Proc. Natl. Acad. Sci. USA, 111: E4963-4971

 

Paduraru, C., Bezbradica, J.S., Kunte, A., Kelly, R., Shayman, J.A, Veerapen, N., Cox, L.R., Besra, G.S., Cresswell, R. (2013).
A Role for Lysosomal Phospholipase A2 in NKT Cell-Mediated CD1d Recognition, Proc. Natl. Acad. Sci. USA, 110: 5097-5102

 

Bezbradica J.S. and Medzhitov R., (2012).
Role of ITAM signaling module in signal integration, Current Opinion in Immunology, 24:58-66 (review)

 

Gordy L.E., Bezbradica, J.S., Flyak, A.I., Spencer, C.T., Dunkle, A., Florence, W.C.,  Stanic, A. K., Sun, J., Zhou, Z.,  He, Y-W., Boothby, M.R., Van Kaer, L. and Joyce, S (2011).
IL-15 regulates homeostasis and terminal maturation of NKT cells. J. Immunol. 187:6335-6345  

 

Bezbradica J.S. and Medzhitov R., (2009).
Integration of cytokine and heterologous receptor signaling pathways, Nature Immunology 10:333-339 (review)

 

Villarino, A.V., Artis, D., Bezbradica, J.S., Miller, O., Saris, C.J.M., Joyce, S., Scott, P., and Hunter, C.A., (2008).
IL-27 receptor-deficiency results in delayed mortality and protection from helminth-induced pathology in a model of chronic IBD, International Immunology, 20:739-752

 

Horng T., Bezbradica J.S., and Medzhitov R. (2007).
NKG2D signaling is coupled with the IL-15 receptor signaling pathway, Nature Immunology, 8:1345-1352

 

Torres, V.J., Stauff, D.L., Pishchany, G., Bezbradica, J.S., Gordy, L.E., Iturregui, J., Anderson, K.L., Dunman, P.M., Joyce, S., and Skaar, E.P., (2007).
A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates Virulence. Cell Host and Microbe, 1:109-119

 

Bezbradica, J.S., Gordy, L.E., Stanic, A.K., Dragovic, S., Hill, T., Hawiger, J., Unutmaz, D., Van Kaer, L., Joyce, S. (2006).
Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny, Immunity, 25:487-497  

 

Bezbradica, J.S.1, Hill, T.1, Stanic, A.K., Van Kaer, L., Joyce, S (2005).
Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc. Natl. Acad. Sci. USA, 102: 5114-5119. 1Joint contribution.

 

Bezbradica, J.S., Stanic, A.K., Matsuki, N., Bour-Jordan, H., Bluestone, J.A., Thomas, J.W., Unutmaz, D., Van Kaer, L. and Joyce, S (2005).
Distinct roles of dendritic cells and B cells in Va14Ja18 natural T (iNKT) cell activation in vivo. J. Immunol. 174: 4696-4705 

 

Stanic, A.K., Bezbradica, J.S., Park, J.J., Matsuki, N., Mora, A.L., Van Kaer, L., Boothby, M.R., Joyce, S (2004).
NF-kB controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J. Immunol. 172: 2265-2273

 

Stanic, A.K., Bezbradica, J.S., Park, J.J., Van Kaer, L., Boothby, M.R., Joyce, S (2004).
The ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C-q and NF-kB. J. Immunol. (Cutting Edge), 172: 4667-4671 

 

Stanic, A.K., Shashidharamurthy, R., Bezbradica, J.S., Matsuki, N., Yoshimura, Y., Miyake, S., Choi, E.Y., Schell, T.D., Van Kaer, L., Tevethia, S.S., Roopenian, D.C., Yamamura, T., Joyce, S. (2004).
Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T (iNKT) cell receptor. J. Immunol. 171: 4539-4551

 

Parekh, V.V., Singh, A.K., Wilson, M.T., Olivares-Villagomez, D. Bezbradica, J.S., Sanazawa, H., Ehara, H., Sakai, T., Serizava, I.,Wu, L., Wang, C., Joyce, S., Van Kaer, L. (2004).
Quantitative and qualitative differences in the in vivo response of NKT cells to distinct a- and b-anomeric glycolipids. J. Immunol. 173: 3693-3706 

 

Nakai, Y., Iwabuchi, K., Fujii, S., Ishimori, N., Dashtsoodol, N., Watano, K., Mishima, T., Iwabuchi, C., Tanaka, S., Bezbradica, J.S., Nakayama, T., Taniguchi, M., Miyake, S., Yamamura, T., Kitabatake, A., Joyce, S., Van Kaer, L., Onoe, K. (2004).
Natural killer T cells accelerate atherogenesis in mice. Blood, 104: 2051-2059

 

Saito, T., Okumura, A., Watanabe, H., Asano, M., Ishida-Okawara, A., Sakagami, J., Sudo, K., Hatano-Yokoe, Y., Bezbradica, J.S., Joyce, S., Abo, T., Iwakura, Y., Suzuki, K., Yamagoe, S. (2004).
Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. J. Immunol, 173: 579-585 

 

REVIEWS AND BOOK CHAPTERS

 

Hill, T.M., Bezbradica J.S., Van Kaer, L., and Joyce, S., (2015).
CD1d-restricted Natural Killer T cells (version 2.0). Encyclopedia of Life Sciences (ELS), Unit A26153, an update on previously published Unit A20180 (John Wiley & Sons, Inc., USA), book chapter,  DOI: 10.1002/9780470015902.a0020180.pub2.

 

Bezbradica J.S., Van Kaer, L., and Joyce, S., (2007).
Natural Killer T cells. Encyclopedia of Life Sciences (ELS), Unit A20180, (John Wiley & Sons, Inc., USA), book chapter

 

Bezbradica J.S., Stanic A.K., and Joyce, S. (2006).
Characterization and functional analysis of murine invariant natural T (iNKT) cells. Current Protocols in Immunology, CPI Unit 14.13, Section: Innate Immunity (John Wiley & Sons, Inc., USA), book chapter

 

Bezbradica, J.S., and Joyce, S. (2005).
Natural T lymphocytes and dendritic cells: An innate duet that arouses and tempers immune responses. Altered Immunoregulation and Human Disease, R. M. Gorczynski, ed. (Trivandrum, India, Research Signpost), pp. 137-163, book chapter