Kaiwen Chen
Dr Kaiwen Chen
PostDoctoral Researcher, Inflammasome Lab
Kaiwen completed his undergraduate studies in Singapore and moved to Brisbane in 2009. After completing his Honours in Professor Alastair McEwan’s laboratory at The University of Queensland investigating metal acquisition during pathogen virulence, he began a PhD in the Inflammasome Lab. Kaiwens' PhD studies involved characterising inflammasome functions in neutrophils. During his PhD Kaiwen achieved 4 first author publications including 2 original research articles, a review and book chapter, in addition to being involved in a further 2 original research articles and an additional review. Kaiwen continues his research in the Inflammasome Lab as a PostDoctoral Researcher.
What do you enjoy about research?
I particularly enjoy the satisfaction of uncovering novel mechanisms regulating cell death and inflammation, which has huge potential to translate into clinically relevant findings.
CONTACTS AND LINKS
Email: kaiwen.chen@imb.uq.edu.au
Office Telephone: +61 7 3346 2351
Lab Telephone: +61 7 3346 2071
Institute for Molecular Bioscience
AWARDS AND PUBLICATIONS
AWARDS, GRANTS AND PRIZES
2015 Australasian Society for Immunology Postgraduate International Travel Award
2014 Network of Immunology Frontier Winter School on Advance Immunology Award
2013 ANZ Trustees PhD Scholarship in Medical Research
2011 The University of Queensland International Scholarship
2011 Institute for Molecular Bioscience Postgraduate Award
2010 Dean’s Commendation for High Achievement, The University of Queensland
2009 Dean’s Commendation for High Achievement, The University of Queensland
EDUCATION
2015 PhD Immunology, The University of Queensland, Australia
2011 Hons Class I Microbiology, The University of Queensland, Australia
2009 Diploma Biotechnology, Temasek Polytechnic, Singapore
27 November 2014, Scientists uncover new intelligence behind inflammatory disease
Kaiwen Chen and the team led by Dr Kate Schroder have uncovered a secret of an immune cell on the frontline that could assist with developing new treatments for inflammatory diseases. “We have found that a type of immune cell doesn’t self-destruct like other cell types in our immunological army, and for this reason, it may be a key driver of inflammatory disease,” Dr Kate Schroder said. The discovery was published in Cell Reports.
ORIGINAL RESEARCH ARTICLES
Conos SA, Chen KW, De Nardo D, Hara H, Whitehead L, Núñez G, Masters SL, Murphy JM, Schroder K, Vaux DL, Lawlor KE, Lindqvist LM, Vince JE. (2017).
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner. Proc Natl Acad Sci U S A Feb7;114(6):E961-969. Pubmed
Chen KW, Bezbradica JS, Gross CJ, Wall AA, Sweet MJ, Stow JL, Schroder K (2016).
The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists. European Journal of Immunology In press. Pubmed
Zamoshnikova A, Groß CJ, Schuster S, Chen KW, Wilson A, Tacchini-Cottier F, Schroder K (2016).
NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling. Immunobiology 221(2):341-6. Pubmed
Sester DP, Thygesen SJ, Sagulenko V, Vajjhala PR, Cridland JA, Vitak N, Chen KW, Osborne GW, Schroder K, Stacey KJ (2015).
A novel flow cytometric method to assess inflammasome formation. Journal of Immunology 194(1):455-462. Pubmed
Chen KW, Gross CJ, Sotomayor F, Stacey KJ, Tschopp J, Sweet MJ, Schroder K (2014).
The neutrophil NLRC4 inflammasome selectively promotes IL-1b maturation without pyroptosis during acute Salmonella challenge. Cell Reports 8: 570-582. Pubmed
Luo L, Wall AA, Yeo JC, Condon ND, Norwood SJ, Schoenwaelder S, Chen KW, Jackson S, Jenkins BJ, Hartland EL, Schroder K, Collins BM, Sweet MJ, Stow JL (2014).
Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications 5:4407.
Achard MES, Chen KW, Schroder K, Sweet MJ, Watt R, Schembri MA, McEwan AG (2013).
An antioxidant role for catechol siderophores in Salmonella. Biochemical Journal 454(3):543-549.
REVIEWS, COMMENTARIES AND BOOK CHAPTERS
Boucher DB, Chen KW, Schroder K (2015).
Burn the house, save the day: pyroptosis in pathogen restriction. Inflammasome 2: 1-6. Inflammasome
Chen KW, Schroder K (2013).
Antimicrobial functions of inflammasomes. Current Opinion in Microbiology 16: 311-318. Pubmed
Chen KW, Richards AA, Zamoshnikova A, Schroder K (2014).
Inflammasomes and inflammation. Chapter 8 in Cancer and Inflammation Mechanisms, Y. Hiraku, S. Kawanishi, H. Ohshima (Editors). (USA: John Wiley and Sons, Inc). Book Chapter. Wiley
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