Nod-like Receptor and Inflammasome Activation Mechanisms

Project Description

Inflammasomes are assembled by innate immune receptor proteins (e.g. Nod-like receptors) but the underlying molecular mechanisms are largely unknown. We seek to understand how inflammasome scaffolds sense cellular ‘danger’ signals, and nucleate the formation of inflammasome complexes.

 

Projects:

  • Mechanisms of NLRP3 activation
  • Molecular determinants of inflammasome assembly

 

Select Publications:

  1. Coll RC, Robertson AA, Chae JJ, Higgins SC, Munoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Nunez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, & O'Neill LA (2015).
    A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nature Medicine 21(3):248-255. Pubmed
     
  2. Guarda G, Zenger M, Yazdi AS, Schroder K, Ferrero I, Menu P, Tardivel A, Mattmann C, & Tschopp J (2011).
    Differential expression of NLRP3 among hematopoietic cells. Journal of Immunology 186(4):2529-2534. Pubmed
     
  3. Schroder K, Zhou R, & Tschopp J (2010).
    The NLRP3 inflammasome: a sensor for metabolic danger? Science 327(5963):296-300. Pubmed
     
  4. Tschopp J & Schroder K (2010).
    NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nature Reviews Immunology 10(3):210-215. Pubmed
     
  5. Schroder K, Muruve DA, & Tschopp J (2009).
    Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. Current Biology 19(6):R262-265. Pubmed

 

Image: Artwork represents an activated inflammasome.

Categories: 
In vivo biology
Microbiology
Molecular biology
Cell biology