Novel Inflammasomes and Pattern Recognition Receptors

Project Description

The Nod-like receptors are a family of pattern-recognition receptors that allow innate immune cells to sense pathogen- and host-derived ‘danger’ signals. The immunological functions of many NLRs remain unknown.

 

Projects:

  • Identification of novel inflammasomes
  • Functional characterisation of novel NLRs

 

Select Publications:

  1. Zamoshnikova A, Groß CJ, Schuster S, Chen KW, Wilson A, Tacchini-Cottier F, Schroder K (2015).
    NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling. Immunobiology 221(2):341-6. Pubmed
     
  2. Staehli F, Ludigs K, Heinz L.X, Seguin-Estevez Q, Ferrero I, Braun M, Schroder K, Rebsamen M, Tardivel A, Mattmann C, Macdonald H.R, Romero P, Reith W, Guarda G, Tschopp J (2012).
    NLRC5 Deficiency Selectively Impairs MHC Class I- Dependent Lymphocyte Killing by Cytotoxic T Cells. Journal of Immunology 188: 3820-3828. Pubmed
     
  3. Heinz LX, Rebsamen M, Rossi DC, Staehli F, Schroder K, Quadroni M, Gross O, Schneider P, Tschopp J (2012).
    The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. Cell Death and Differentiation 19: 722-731. Pubmed
     
  4. Cridland JA, Curley EZ, Wykes MN, Schroder K, Sweet MJ, Roberts TL, Ragan MA, Kassahn KS, Stacey KJ (2012).
    The mammalian PYHIN gene family: phylogeny, evolution and expression. BMC Evolutionary Biology 12: 140. Pubmed
     
  5. Rebsamen M, Heinz LX, Meylan E, Michallet MC, Schroder K, Hofmann K, Vazquez J, Benedict CA, Tschopp J (2009).
    DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Reports 10: 916-922. Pubmed
     
  6. Wells CA, Salvage-Jones JA, Li X, Hitchens K, Butcher S, Murray RZ, Beckhouse AG, Lo YL, Manzanero S, Cobbold C, Schroder K, Ma B, Orr S, Stewart L, Lebus D, Sobieszczuk P, Hume DA, Stow J, Blanchard H, Ashman RB (2008).
    The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. Journal of Immunology 180: 7404-7413. Pubmed

 

Image: Artwork represents identification of novel inflammasomes.

Categories: 
Cell biology
Molecular biology