ARC Discovery project on pyroptosis shaping immune responses

The Inflammasome Lab are delighted to receive a 2023 ARC Discovery grant to follow up on Dr Caroline Holley’s exciting discoveries of how pyroptosis shapes immune responses.  

Project Title: Pyroptotic macrophages posthumously sculpt immune responses

The life of an organism relies on the timely birth and death of its cells. Importantly, it is crucial for cells to die not only at the right time, but also in an appropriate manner. This proposal investigates a cell death pathway that triggers potent immune responses. This proposal seeks to reveal precisely how cell death sculpts immune responses. Expected outcomes include new insights into how immune cells die, and how they instruct immune responses from beyond the grave. Project benefits include a fundamental understanding of how cell death signalling sculpts tissue immune responses, and knowledge of how to manipulate cell death responses for future basic research and commercial applications beyond this project.