Dr Caroline Holley


Dr Caroline Holley


Postdoctoral Researcher
Inflammasome Lab



Caroline joined the Inflammasome Lab in 2014 for a postgraduate Honours project supervised by Dr Kate Schroder. Her project involved using a flow cytometry-based assay to screen a panel of pattern recognition receptors for the ability to trigger oligomerisation of the inflammasome adaptor ASC. Caroline's research earned her a First Class Honours. In 2015, Caroline returned to the Inflammasome Lab as a research assistant. In January 2017, Caroline began her PhD in inflammation research.




Email: c.holley@uq.edu.au

Office Telephone: +61 7 3346 2351

Lab Telephone: +61 7 3346 2356


Institute for Molecular Bioscience








2018  Winner, ATA Scientific Encouragement Award


2017  PhD research support, The Yulgilbar Alzheimer's Research Program


2017  Global Change Scholar, The University of Queensland




2014  BSc Honours, Supervisor: Dr Kate Schroder, The University of Queensland


2013  Bachelor of Science, The University of Queensland




Holley CL, Schroder K. (2020).
The rOX-stars of inflammation: links between the inflammasome and mitochondrial meltdown. Clinical and Translational Immunology. 2020 Feb 10; 9(2): e01109. doi:10.1002/cti2.1109. Pubmed

Holley CL, Coll RC, Schroder K (2018).
NLRC3 Restrains Responses to a T. Immunity Dec 18;49(6):989-991. Pubmed
Comment on:
The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity. Uchimura T et al 2018 Immunity.


Coll RC, Holley CL, Schroder K (2018).
Mitochondrial DNA synthesis fuels the NLRP3 inflammasome. Cell Research In press. Pubmed

Comment on:
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Zhong Z et al 2014 Nature.


Monteleone M, Stanley AC, Chen KW, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D, Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K. (2018).
Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion. Cell Reports Aug 7;24(6):1425-1433. Pubmed


Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS and Schroder K. (2018).
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine In press. Pubmed
1Equal contribution

See Journal of Experimental Medicine for a complete list of citations, reviews and media attention this publication has recieved. Read the news articles here

Reseach Highlight:
Defusing inflammasomes. Sandstrom A, Vance RE. Journal of Experimental Medicine. Pubmed


Hill JR, Coll RC, Sue N, Reid JC, Dou J, Holley CL, Pelingon R, Dickinson JB, Biden TJ, Schroder K, Cooper MA, Robertson AAB. (2017).
Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors. Chem Med Chem Sep 7;12(17):1449-1457. Pubmed


Masters SL, Lagou V, Jéru I, Baker PJ, Van Eyck L, Parry DA, Lawless D, De Nardo D, Garcia-Perez JE, Dagley LF, Holley CL, Dooley J, Moghaddas F, Pasciuto E, Jeandel PY, Sciot R, Lyras D, Webb AI, Nicholson SE, De Somer L, van Nieuwenhove E, Ruuth-Praz J, Copin B, Cochet E, Medlej-Hashim M, Megarbane A, Schroder K, Savic S, Goris A, Amselem S, Wouters C, Liston A (2016).
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. Science Translational Medicine Mar 30;8(332):332ra45. Pubmed

Comment in:
Mutation implicated in auto-inflammatory disease. Nature Middle East