Dr Larisa Labzin

 

Dr Larisa Labzin

(she, her)
 
Senior Postdoctoral Research Fellow
Inflammasome Lab (Labzin Team)

 

 

Larisa’s long standing interest in innate immunity started during her honours training with Prof. Kate Schroder and Prof. Matt Sweet at IMB. She did her PhD at the University of Bonn, Germany, with Prof. Eicke Latz, and was an EMBO and NHMRC CJ Martin Postdoctoral Fellow with Dr Leo James in Cambridge UK. Larisa’s PhD and postdoctoral research investigated how serum components (HDL, antibodies), regulate macrophage inflammatory responses. Since returning to Australia Larisa has secured multiple grants to study the molecular mechanisms of virus-induced inflammation, and how this affects viral clearance and disease pathology.

 

As an IMB fellow, Larisa leads an independent team researching influenza and SARS-CoV-2.

 

Current Supervision

Kathrin Eschke - Postdoctoral researcher (commenced July 2022)

Xiahoui Wang - PhD (commenced April 2021)

Tyron Esposito - PhD (commenced April 2022)

 

Previous Supervision

Tyron Esposito - Honours (February-November 2021)

Claudia Stocks - Postdoctoral researcher (May-Dec 2020)

 

"In theory, there is no difference between theory and practice. But, in practice, there is.”

Manfred Eigen

 

CONTACTS AND LINKS

 

Email: l.labzin@uq.edu.au

Office Telephone: + 61 7 3346 2051

 

Institute for Molecular Bioscience

Google Scholar

Twitter

 

AWARDS AND PUBLICATIONS

 

 

AWARDS, GRANTS AND PRIZES

 

2020 Institute for Molecular Bioscience Impact Award for Response to COVID-19. Brisbane, Australia.

2020 UQ Early Career Researcher (UQ ECR) Grant, sole investigator ($20 000). Brisbane, Australia.

2019 Finalist for the Life Sciences Queensland Rose Anne Kelso Commemorative Award for Excellent Women in Science. Brisbane, Australia.

2017 Research Excellence Award, Frank Fenner Early Career Fellowship Award, NHMRC, Australia.

2017 Postdoctoral Fellow Scholarship, CJ Martin Overseas Biomedical Fellowship, NHMRC, Australia.

2016 Postdoctoral Fellow Scholarship, EMBO Long Term Fellowship, Germany.

2016 Travel Award, Weizmann Institute of Science, to attend Next Gen Immunology 2016, Tel Aviv, Israel.

2015 Travel Award, the Maria von Linden Program, University of Bonn, to attend Toll 2015, Marbella, Spain.

2015 Prize for best poster presentation, Innate Immune Memory, Cambridge, UK.

2015 Travel Award, the Wellcome Trust Advanced Courses and Scientific Conferences, to attend Innate Immune Memory, Cambridge, UK.

2015 Travel Award, Deutsche Akademische Austausch Dienst (DAAD) - German Academic Exchange Service, to attend Cytokines, San Francisco, USA.

2013 Prize for best Oral Presentation, Cluster of Excellence Immunosensation, inaugural Cluster Science Day, Bonn, Germany.

 

EDUCATION

 

2015  Dr.rer.nat. (PhD), Molecular Biomedicine, Faculty of Mathematics and Natural Sciences, Rheinische Friedrich-Wilhelms University of Bonn, Germany. Grade: summa cum laude

2007  BSc Honors (Microbiology), Institute of Molecular Bioscience, University of Queensland, Australia.

2006  BA (German, International Relations), BSc (Biochemistry), University of Queensland, Australia.

 

 

Schimmel L, Chew KY, Stocks CJ, Yordanov TE, Essebier P, Kulasinghe A, Monkman J, Dos Santos Miggiolaro AFR, Cooper C, de Noronha L, Schroder K, Lagendijk AK, Labzin LI, Short KR, Gordon EJ. (2021).
Endothelial cells are not productively infected by SARS-CoV-2. Clinical and Translational Immunology Oct 24;10(10):e1350. Pubmed

 

Hulme KD, Noye EC, Short KR, Labzin LI. (2021).
Dysregulated Inflammation During Obesity: Driving Disease Severity in Influenza Virus and SARS-CoV-2 Infections. Frontiers in Immunology Oct 28;12:770066. Pubmed

 

Labzin LI, Bottermann M, Rodriguez-Silvestre P, Foss S, Andersen JT, Vaysburd M, Clift D, James LC. (2019).
Antibody and DNA sensing pathways converge to activate the inflammasome during primary human macrophage infection. EMBO Journal Epub ahead of print.

 

Castro-Dopico T, Dennison TW, Ferdinand JR, Mathews RJ, Fleming A, Clift D, Stewart BJ, Jing C, Strongili K, Labzin LI, Monk EJM, Saeb-Parsy K, Bryant CE, Clare S, Parkes M, Clatworthy MR. (2019).
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis. Immunity Apr 16;50(4):1099-1114.e10. Pubmed

 

Clift D, McEwan WA, Labzin LI, Konieczny V, Mogessie B, James LC, Schuh M. (2017).
A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell Dec 14;171(7):1692-1706.e18. Pubmed

 

Labzin LI, Henneka, M, Latz E. (2018).
Innate Immunity and Neurodegeneration. Annual Reviews of Medicine Jan 29;69:437-449. Pubmed

 

Labzin LI, Lauterbach MA, Latz E. (2016).
Interferons and inflammasomes: Cooperation and counterregulation in disease. The Journal of Allergy and Clinical Immunology Jul;138(1):37-46. Pubmed

 

Zimmer S, Grebe A, Bakke SS, Bode N, Halvorsen B, Ulas T, Skjelland M, De Nardo D, Labzin LI, Kerksiek A, Hempel C, Heneka MT, Hawxhurst V, Fitzgerald ML, Trebicka J, Björkhem I, Gustafsson JÅ, Westerterp M, Tall AR, Wright SD, Espevik T, Schultze JL, Nickenig G, Lütjohann D, Latz E. (2016).
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming. Science Translational Medicine Apr 6;8(333):333ra50. Pubmed

 

Labzin LI, Schmidt SV, Masters SL, Beyer M, Krebs W, Klee K, Stahl R, Lütjohann D, Schultze JL, Latz E, De Nardo D. (2015).
ATF3 is a key regulator of macrophage interferon-responses. Journal of Immunology Nov 1;195(9):4446-55. Pubmed

 

Krebs, W., Schmidt, S.V., Goren, A., De Nardo, D., Labzin, L., Bovier, A., Ulas, T., Theis, H., Kraut, M., Latz, E., Beyer, M. and Schultze, J. (2014).
Optimization of transcription factor binding map accuracy utilizing knockout-mouse models. Nucleic Acids Research Dec 1;42(21):13051-60. Pubmed

 

Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk JL, Schmidt T, Spille JH, Labzin LI, Agrawal S, Kandimalla ER, Casanova JL, Hornung V, Marshak-Rothstein A, Höning S, Latz E. (2014).
Cutting Edge: The UNC93B1 Tyrosine-Based Motif Regulates Trafficking and TLR Responses via Separate Mechanisms. The Journal of Immunology Oct 1;193(7):3257-61. Pubmed

 

Xue J, Schmidt SV, Sander J, Draffehn A, Krebs W, Quester I, De Nardo D, Gohel TD, Emde M, Schmidleithner L, Ganesan H, Nino-Castro A, Mallmann MR, Labzin L, Theis H, Kraut M, Beyer M, Latz E, Freeman TC, Ulas T, Schultze JL. (2014).
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity Feb 20;40(2):274-88. Pubmed

Selected for:
Faculty of 1000 highlight

 

De Nardo D1, Labzin LI1, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Röcken M, Lütjohann D, Wright SD, Schultze JL, Latz E. (2014).
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nature Immunology Feb;15(2):152-60. Pubmed
1Equal contribution

Highlighted in:
Old HDL learns a new (anti-inflammatory) trick. Odegaard, J. I. and Chawla, A., 2014 Nature Immunology. Highlighted in:
High Density Lipoproteins Put Out the Fire. Moore, K. J. and Fisher, E. A., 2014 Cell Metabolism. Highlighted in:
The anti-inflammatory effects of HDL through ATF3: benefit beyond cholesterol transport-dependent processes. Zhang, H.R. and Reilly, M.P. 2014 Nature.

Selected for:
Faculty of 1000 highlight

 

Shakespear MR, Hohenhaus DM, Kelly GM, Kamal NA, Gupta P, Labzin LI, Schroder K, Garceau V, Barbero S, Iyer A, Hume DA, Reid RC, Irvine KM, Fairlie DP, Sweet MJ. (2013).
Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages. Journal of Biological Chemistry Aug 30;288(35):25362-74. Pubmed

 

Schroder K, Irvine KM, Taylor MS, Bokil NJ, Le Cao KA, Masterman KA, Labzin LI, Semple CA, Kapetanovic R, Fairbairn L, Akalin A, Faulkner GJ, Baillie JK, Gongora M, Daub CO, Kawaji H, McLachlan GJ, Goldman N, Grimmond SM, Carninci P, Suzuki H, Hayashizaki Y, Lenhard B, Hume DA, Sweet MJ. (2012).
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages. Proceedings of the National Academy of Sciences Apr 17;109(16):E944-53. Pubmed

 

De Nardo D, Vogelhuber J, Labzin L, Langhoff P, Latz E. (2012).
Inflammasomopathies: Diseases Linked to the NLRP3 Inflammasome. New-Opathies, An Emerging Molecular Reclassification of Human Disease pp.23-65, Friedberg, E.C., Castrillon, D.H., Galindo, R.L., Wharton, K (Editors). (Singapore: World Scientific Publishing Company) World Scientific Publishing Company

 

Christ AN1, Labzin L1, Bourne GT, Fukunishi H, Weber JE, Sweet MJ, Smythe ML, Flanagan JU. (2010).
Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases. Journal of Medicinal Chemistry Aug 12;53(15):5536-48. Pubmed
1Equal contribution

 

Halili MA, Andrews MR, Labzin LI, Schroder K, Matthias G, Cao C, Lovelace E, Reid RC, Le GT, Hume DA, Irvine KM, Matthias P, Fairlie DP, Sweet MJ. (2010).
Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology Jun;87(6):1103-14. Pubmed