"Research is what I'm doing when I don't know what I'm doing"
Wernher von Braun
Email: m.monteleone@imb.uq.edu.au
Office Telephone: +61 7 3346 2078
Institute for Molecular Bioscience
AWARDS, GRANTS AND PRIZES
2020 Discovery Early Career Research Award (DECRA), Australian Research Council, Australia.
EDUCATION
2013 PhD (Microbiology and Immunology), University of Sydney.
2002 Master of Science (Microbiology), Universidad Nacional Rio Cuarto.
Thygesen SJ, Burgener SS, Mudai P, Monteleone M, Boucher D, Sagulenko V, Schroder K, Stacey KJ (2024).
Fluorochrome-labeled inhibitors of caspase-1 require membrane permeabilization to efficiently access caspase-1 in macrophages. European Journal of Immunology May;54(5):e2350515. Pubmed
Emming S, Monteleone MM, Kambara H, Starchenko A, Alley J, Nolan MA, Li W, Kilty I, Schroder K (2023).
Quantifying Cell Death Induced by the NLRC4 Inflammasome. Methods in Molecular Biology 2696:199-210. Pubmed
Richter J, Monteleone MM, Cork AJ, Barnett TC, Nizet V, Brouwer S, Schroder K, Walker MJ. (2021).
Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology & Cell Biology Nov;99(10):1040-1052. Pubmed
Starobova H, Monteleone M, Adolphe C, Batoon L, Sandrock CJ, Tay B, Deuis JR, Smith AV, Mueller A, Nadar EI, Lawrence GP, Mayor A, Tolson E, Levesque JP, Pettit AR, Wainwright BJ, Schroder K, Vetter I. (2021).
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine. May 3;218(5):e20201452. doi: 10.1084/jem.20201452. Pubmed
Bierschenk D, Monteleone M, Moghaddas F, Baker PJ, Masters SL, Boucher D, Schroder K (2019).
The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses. Journal of Leukocyte Biology 105(2):401-410. Pubmed
Monteleone M, Stanley AC1, Chen KW1, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D,. Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K. (2018).
Interleukin-1b maturation triggers its relocation to the plasma membrane for Gasdermin-D-dependent and -independent secretion. Cell Reports Aug 7;24(6):1425-1433. Pubmed
1Equal contribution
Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS and Schroder K. (2018).
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine 215(3):827-840. Pubmed
1Equal contribution
Chen KW1, Monteleone M1, Boucher D1, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K. (2018).
The non-canonical inflammasome provides host defense via GSDMD- dependent neutrophil extracellular traps. Science Immunology Aug 24;3(26). Pubmed
1Equal contribution
Kapetanovic R, Bokil NJ, Achard ME, Ong CL, Peters KM, Stocks CJ, Phan MD, Monteleone M, Schroder K, Irvine KM, Saunders BM, Walker MJ, Stacey KJ, McEwan AG, Schembri MA, Sweet MJ (2016).
Salmonella employs multiple mechanisms to subvert TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal. May;30(5):1901-12. Pubmed
Baker PJ, Boucher D, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K, Masters SL (2015).
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5 European Journal of Immunology Oct;45(10):2918-26. Pubmed
Monteleone M, Stow JL, Schroder K (2015).
Mechanisms of unconventional secretion of Il-1 family cytokines. Cytokine Aug;74(2):213-8. Pubmed
Kim J, O’Brien KM, Sharma R, Boshoff H, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC, Barry CE, Rhee K, Ehrt S, and Schnappinger D (2013).
A novel genetic switch identifies the Mycobacterium tuberculosis NAD synthetase as a target for the development of improved Tuberculosis chemotherapies. Proceedings of the National Academy of Science U S A vol 110, No 47, pp 19095 – 19100.
Ly D, Taylor JM, Tsatsaronis JA, Monteleone MM, Skora AS, Donald CA, Maddocks T, Nizet V, West NP, Ranson M, Walker MJ, McArthur JD, Sanderson-Smith ML (2013).
Plasmin(ogen) Acquisition by Group A Streptococcus Protects Against C3b-Mediated Neutrophil Killing. Journal of Innate Immunity Aug 20. Pubmed
Gandotra S, Schnappinger D, Monteleone M, Hillen W , Ehrt S (2007).
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nature Medicine Dec;13(12):1515-20. Pubmed
Guo XV, Monteleone M, Klotzsche M, Kamionka A, Hillen W, Braunstein M, Ehrt S, Schnappinger D (2007).
Silencing Mycobacterium smegmatis by using tetracycline repressors. Journal of Bacteriology JJul;189(13):4614-23. Pubmed
Ehrt S, Guo XV, Hickey CM, Ryou M, Monteleone M, Riley LW, Schnappinger D (2005).
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acid Research Feb 1;33(2):e21. Pubmed
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