Dr Mercedes Monteleone


Dr Mercedes Monteleone


Senior Postdoctoral Research Fellow
Inflammasome Lab



In 2013, Mercedes obtained her PhD in Microbiology and Immunology at The Centenary Institute of Cancer Medicine and Cell Biology in Sydney, then joined the Inflammasome Lab in 2014 as a Postdoctoral Researcher. Her research focuses on understanding host-pathogen interactions and the recognition of intracellular pathogens by inflammasomes.


"Research is what I'm doing when I don't know what I'm doing"

Wernher von Braun




Email: m.monteleone@imb.uq.edu.au

Office Telephone: +61 7 3346 2078


Institute for Molecular Bioscience

Google Scholar

Research Gate







2020 Discovery Early Career Research Award (DECRA), Australian Research Council, Australia.




2013 PhD (Microbiology and Immunology), University of Sydney.

2002 Master of Science (Microbiology), Universidad Nacional Rio Cuarto.



Thygesen SJ, Burgener SS, Mudai P, Monteleone M, Boucher D, Sagulenko V, Schroder K, Stacey KJ (2024).
Fluorochrome-labeled inhibitors of caspase-1 require membrane permeabilization to efficiently access caspase-1 in macrophages. European Journal of Immunology  May;54(5):e2350515. Pubmed


Emming S, Monteleone MM, Kambara H, Starchenko A, Alley J, Nolan MA, Li W, Kilty I, Schroder K (2023).
Quantifying Cell Death Induced by the NLRC4 Inflammasome. Methods in Molecular Biology 2696:199-210. Pubmed


Richter J, Monteleone MM, Cork AJ, Barnett TC, Nizet V, Brouwer S, Schroder K, Walker MJ. (2021).
Streptolysins are the primary inflammasome activators in macrophages during Streptococcus pyogenes infection. Immunology & Cell Biology Nov;99(10):1040-1052. Pubmed


Starobova H, Monteleone M, Adolphe C, Batoon L, Sandrock CJ, Tay B, Deuis JR, Smith AV, Mueller A, Nadar EI, Lawrence GP, Mayor A, Tolson E, Levesque JP, Pettit AR, Wainwright BJ, Schroder K, Vetter I. (2021).
Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine. May 3;218(5):e20201452. doi: 10.1084/jem.20201452. Pubmed


Bierschenk D, Monteleone M, Moghaddas F, Baker PJ, Masters SL, Boucher D, Schroder K (2019).
The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses. Journal of Leukocyte Biology 105(2):401-410. Pubmed


Monteleone M, Stanley AC1, Chen KW1, Brown DL, Bezbradica JS, von Pein JB, Holley CL, Boucher D,. Shakespear MR, Kapetanovic R, Rolfes V, Sweet MJ, Stow JL, Schroder K. (2018).
Interleukin-1b maturation triggers its relocation to the plasma membrane for Gasdermin-D-dependent and -independent secretion. Cell Reports Aug 7;24(6):1425-1433. Pubmed
1Equal contribution


Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS and Schroder K. (2018).
Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine 215(3):827-840. Pubmed
1Equal contribution


Chen KW1, Monteleone M1, Boucher D1, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K. (2018).
The non-canonical inflammasome provides host defense via GSDMD- dependent neutrophil extracellular traps. Science Immunology Aug 24;3(26). Pubmed
1Equal contribution


Kapetanovic R, Bokil NJ, Achard ME, Ong CL, Peters KM, Stocks CJ, Phan MD, Monteleone M, Schroder K, Irvine KM, Saunders BM, Walker MJ, Stacey KJ, McEwan AG, Schembri MA, Sweet MJ (2016).
Salmonella employs multiple mechanisms to subvert TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal. May;30(5):1901-12. Pubmed


Baker PJ, Boucher D, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K, Masters SL (2015).
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5 European Journal of Immunology Oct;45(10):2918-26. Pubmed


Monteleone M, Stow JL, Schroder K (2015).
Mechanisms of unconventional secretion of Il-1 family cytokines. Cytokine Aug;74(2):213-8. Pubmed



Kim J, O’Brien KM, Sharma R, Boshoff H, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC, Barry CE, Rhee K, Ehrt S, and Schnappinger D (2013).
A novel genetic switch identifies the Mycobacterium tuberculosis NAD synthetase as a target for the development of improved Tuberculosis chemotherapies. Proceedings of the National Academy of Science U S A vol 110, No 47, pp 19095 – 19100.


Ly D, Taylor JM, Tsatsaronis JA, Monteleone MM, Skora AS, Donald CA, Maddocks T, Nizet V, West NP, Ranson M, Walker MJ, McArthur JD, Sanderson-Smith ML (2013).
Plasmin(ogen) Acquisition by Group A Streptococcus Protects Against C3b-Mediated Neutrophil Killing. Journal of Innate Immunity Aug 20. Pubmed


Gandotra S, Schnappinger D, Monteleone M, Hillen W , Ehrt S (2007).
In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nature Medicine Dec;13(12):1515-20. Pubmed


Guo XV, Monteleone M, Klotzsche M, Kamionka A, Hillen W, Braunstein M, Ehrt S, Schnappinger D (2007).
Silencing Mycobacterium smegmatis by using tetracycline repressors. Journal of Bacteriology JJul;189(13):4614-23. Pubmed


Ehrt S, Guo XV, Hickey CM, Ryou M, Monteleone M, Riley LW, Schnappinger D (2005).
Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acid Research Feb 1;33(2):e21. Pubmed