Dr Stefan Emming


Dr Stefan Emming

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Postdoctoral Research Fellow
Inflammasome Lab



Stefan has a long-standing interest in trying to understand cellular processes at a detailed molecular level. He did his Master in Biochemistry in a Structural Biology lab, investigating the structure and function of the intracellular innate immune sensors AIM2 and STING. Following a short period at the Biozentrum in Basel (Switzerland), Stefan joined the Molecular Immunology lab of S. Monticelli at the Institute for Research in Biomedicine (Bellinzona, Switzerland) to conduct a PhD. After a deep dive into transcriptional and post-transcriptional regulation of gene expression in T cells during his PhD, Stefan joined the Inflammasome Lab in 2019 as a Postdoc. His research is focused on the multi-step mechanism of inflammasome activation and its regulation on a molecular level.


"A scientist in his laboratory is not only a technician: he is also a child placed before natural phenomena which impress him like a fairy tale.”

Marie Curie




Email: s.emming@uq.edu.au

Office Telephone: +61 7 3346 2076


Institute for Molecular Bioscience

Google Scholar









2018  World Immune Regulation Meeting XII, Davos, Switzerland. EFIS-EJI Travel grant, BioLegend Best Presentation Award of Workshop “Systems biology”




2019  PhD in Immunology, Institute for Research in Biomedicine, Bellinzona, Switzerland.

2012  Master of Science in Biochemistry, Ludwig-Maximilians-University Munich, Germany.

2009  Bachelor of Science in Life Sciences, University of Konstance, Germany.

Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K (2024).
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling 17(820):eabg8145. Pubmed


Yap JK, Emming S, Schroder K (2024).
Oxidized thioredoxin 1 places a leash on NLRP1 inflammasome activity. Immunology and Cell Biology 102(1):5-7. Pubmed


Emming S, Monteleone MM, Kambara H, Starchenko A, Alley J, Nolan MA, Li W, Kilty I, Schroder K (2023).
Quantifying Cell Death Induced by the NLRC4 Inflammasome. Methods in Molecular Biology 2696:199-210. Pubmed


Mellacheruvu M, Lawrence GMEP, Emming S, Schroder K (2023).
Reversing the mitochondrial hex that bewitches NLRP3. Science Immunology 8(84):eadh2967. Pubmed


Labzin LI, Chew KY, Eschke K, Wang X, Esposito T, Stocks CJ, Rae J, Patrick R, Mostafavi H, Hill B, Yordanov TE, Holley CL, Emming S, Fritzlar S, Mordant FL, Steinfort DP, Subbarao K, Nefzger CM, Lagendijk AK, Gordon EJ, Parton RG, Short KR, Londrigan SL, Schroder K (2023).
Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release. Science Signaling 16(782):eabq1366. Pubmed


Emming S, Schroder K (2019).
Tiered DNA sensors for escalating responses. Science Sep 27;365(6460):1375-1376. Pubmed

Find also:
Summary from Science, Reprint from Science, and Full text from Science



Emming S, Bianchi N, Polletti S, Balestrieri C, Leoni C, Montagner S, Chirichella M, Delaleu N, Natoli G, Monticelli S. (2020).

A molecular network regulating the proinflammatory phenotype of human memory T lymphocytes. Nature Immunology Apr;21(4):388-399 doi: 10.1038/s41590-020-0622-8. Pubmed


Bianchi N, Emming S, Zecca C, Monticelli S. (2020).
Vitamin D and IFN-β Modulate the Inflammatory Gene Expression Program of Primary Human T Lymphocytes. Frontiers in Immunology Dec 4;11:566781. doi: 10.3389/fimmu.2020.566781. Pubmed


Sacco R, Emming S, Gobbi C, Zecca C, Monticelli S. (2020).
Rebound of disease activity after fingolimod withdrawal: Immunological and gene expression profiling. Multiple Sclerosis and Related Disorders May;40:101927. doi: 10.1016/j.msard.2020.101927. Pubmed


Emming S, Chirichella M, Monticelli S. (2018).
MicroRNAs as modulators of T cell functions in cancer. Cancer Letters Aug 28;430:172-178. Pubmed


Montagner S, Leoni C, Emming S, Della Chiara G, Balestrieri C, Barozzi I, Piccolo V, Togher S, Ko M, Rao A, Natoli G, Monticelli S. (2016).
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Reports May 17;15(7):1566-1579. Pubmed


Leoni C, Vincenzetti L, Emming S, Monticelli S. (2015).
Epigenetics of T lymphocytes in health and disease. Swiss Medical Weekly Oct 23;145:w14191. Pubmed