Remember to look up at the stars and not down at your feet.
Stephen Hawking
Email: e.lesieur@imb.uq.edu.au
Telephone (direct line): +61 7 3346 2347
Telephone (Schroder Group line): +61 7 3346 2356
Institute for Molecular Bioscience
EDUCATION
2005 Master of Science in Industrial Biology, Ecole de Biologie Industrielle, France
2002 Honours in Molecular Biology, Ecole Superieure des technologies de Biologie Appliquee, France
2001 Bachelor of Science in Biochemistry, Ecole Jean-Baptiste Poquelin, France
Burgener SS, Milner MT, Dey S, Morgan PK, Blackmore DG, Frampton E, Miller G, Duarte de Oliveira M, Kenney KM, Bajracharya R, Baumgartner U, Collins TJC, Xiong Z, Nguyen Q, Meikle PJ, Bodea L-G, Clouston A, Boucher D, Götz J, Murphy AJ, Kaye PM, Schroder K (2025).
Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases. BioRxiv doi: 10.1101/2025.04.28.651119.
Pizzuto M, Monteleone M, Burgener SS, Began J, Kurera M, Chia JR, Frampton E, Crawford J, Oliveira M, Kenney KM, Coombs JR, Yamamoto M, Man SM, Broz P, Pelegrin P, Schroder K (2025).
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11. EMBO Journal 44(16):4419-4442. Pubmed
Frampton, Emmanuelle, Som, Priyanka, Hill, Brittany, Yu, Alexander, Naval-Sanchez, Marina, Nefzger, Chistian M., Noordstra, Ivar, Gordon, Emma and Schimmel, Lilian (2024).
Endothelial c-Src mediates neovascular tuft formation in oxygen-induced retinopathy. The American Journal of Pathology, 194 (12), 2239-2251. doi: 10.1016/j.ajpath.2024.09.003
Vion, Anne-Clémence, Perovic, Tijana, Petit, Charlie, Hollfinger, Irene, Bartels-Klein, Eireen, Frampton, Emmanuelle, Gordon, Emma, Claesson-Welsh, Lena and Gerhardt, Holger (2021).
Endothelial cell orientation and polarity are controlled by shear stress and VEGF through distinct signaling pathways. Frontiers in Physiology, 11 623769, 623769. doi: 10.3389/fphys.2020.623769
Schimmel, Lilian, Fukuhara, Daisuke, Richards, Mark, Jin, Yi, Essebier, Patricia, Frampton, Emmanuelle, Hedlund, Marie, Dejana, Elisabetta, Claesson-Welsh, Lena and Gordon, Emma (2020).
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly. Development, 147 (7) 185405, dev.185405. doi: 10.1242/dev.185405
Overman, Jeroen, Fontaine, Frank, Wylie-Sears, Jill, Moustaqil, Mehdi, Huang, Lan, Meurer, Marie, Chiang, Ivy Kim, Lesieur, Emmanuelle, Patel, Jatin, Zuegg, Johannes, Pasquier, Eddy, Sierecki, Emma, Gambin, Yann, Hamdan, Mohamed, Khosrotehrani, Kiarash, Andelfinger, Gregor, Bischoff, Joyce and Francois, Mathias (2019).
R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma. eLife, 8 e43026. doi: 10.7554/elife.43026
Pichol-Thievend, Cathy, Betterman, Kelly L., Liu, Xiaolei, Ma, Wanshu, Skoczylas, Renae, Lesieur, Emmanuelle, Bos, Frank L., Schulte, Dorte, Schulte-Merker, Stefan, Hogan, Benjamin M., Oliver, Guillermo, Harvey, Natasha L. and Francois, Mathias (2018).
A blood capillary plexus-derived population of progenitor cells contributes to genesis of the dermal lymphatic vasculature during embryonic development. Development, 145 (10) dev160184, dev160184. doi: 10.1242/dev.160184
Chiang, Ivy Kim-Ni, Fritzsche, Martin, Pichol-Thievend, Cathy, Neal, Alice, Holmes, Kelly, Lagendijk, Anne, Overman, Jeroen, D'Angelo, Donatella, Omini, Alice, Hermkens, Dorien, Lesieur, Emmanuelle, Liu, Ke, Ratnayaka, Indrika, Corada, Monica, Bou-Gharios, George, Carroll, Jason, Dejana, Elisabetta, Schulte-Merker, Stefan, Hogan, Benjamin, Beltrame, Monica, De Val, Sarah and Francois, Mathias (2017).
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development, 144 (14), 2629-2639. doi: 10.1242/dev.146241
Overman, Jeroen, Fontaine, Frank, Moustaqil, Mehdi, Mittal, Deepak, Sierecki, Emma, Sacilotto, Natalia, Zuegg, Johannes, Robertson, Avril A. B., Holmes, Kelly, Salim, Angela A., Mamidyala, Sreeman, Butler, Mark S., Robinson, Ashley S., Lesieur, Emmanuelle, Johnston, Wayne, Alexandrov, Kirill, Black, Brian L., Hogan, Benjamin M., De Val, Sarah, Capon, Robert J., Carroll, Jason S., Bailey, Timothy L., Koopman, Peter, Jauch, Ralf, Smyth, Mark J., Cooper, Matthew A., Gambin, Yann and Francois, Mathias (2017).
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. eLife, 6 e21221. doi: 10.7554/eLife.21221
Coxam, Baptiste, Sabine, Amelie, Bower, Neil I., Smith, Kelly A., Pichol-Thievend, Cathy, Skoczylas, Renae, Astin, Jonathan W., Frampton, Emmanuelle, Jaquet, Muriel, Crosier, Philip S., Parton, Robert G., Harvey, Natasha L., Petrova, Tatiana V., Schulte-Merker, Stefan, Francois, Mathias and Hogan, Benjamin M. (2014).
Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Reports, 7 (3), 623-633. doi: 10.1016/j.celrep.2014.03.063
Bowles, Josephine, Secker, Genevieve, Nguyen, Christelle, Kazenwadel, Jan, Truong, Vy, Framptom, Emmanuelle, Curtis, Cameron, Skoczylas, Renae, Davidson, Tara-Lynn, Miura, Naoyuki, Hong, Young-Kwon, Koopman, Peter, Harvey, Natasha L. and François, Mathias (2014).
Control of retinoid levels by CYP26B1 is important for lymphatic vascular development in the mouse embryo. Developmental Biology, 386 (1), 25-33. doi: 10.1016/j.ydbio.2013.12.008
Kartopawiro, Joëlle, Neil Bower, Neil I., Karnezis, Tara, Kazenwadel, Jan, Betterman, Kelly L., Lesieur, Emmanuelle, Koltowska, Katarzyna, Astin, Jonathan, Crosier, Philip, Vermeren, Sonja, Achen, Marc G., Stacker, Steven A., Smith, Kelly A., Harvey, Natasha L., François, Mathias and Hogan, Benjamin M. (2013).
Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human Molecular Genetics, Advance Access (5) ddt518, 1-12. doi: 10.1093/hmg/ddt518
Chen, Huijun, Palmer, James S., Thaigarajan, Rathi D., Dinger, Marcel E., Frampton, Emmanuelle, Chiu, Hansheng, Schulz, Alexandra, Spiller, Cassy, Grimmond, Sean M., Little, Melissa H., Koopman, Peter A. and Wilhelm, Ingrid D. (2012).
Identification of novel markers of mouse fetal ovary development. PLoS One, 7 (7) e41683, e41683.1-e41683.15. doi: 10.1371/journal.pone.0041683
Georgas, K. M., Chiu, H. S., Lesieur, E., Rumballe, B. A. and Little, Melissa H. (2011).
Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Developmental Dynamics, 240 (6), 1600-1612. doi: 10.1002/dvdy.22640
Thiagarajan, Rathi D., Georgas, Kylie M., Rumballe, Bree A., Lesieur, Emmanuelle, Chiu, Han Sheng, Taylor, Darrin, Tang, Dave T. P., Grimmond, Sean M. and Little, Melissa H. (2011).
Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One, 6 (2) e17286, 1-15. doi: 10.1371/journal.pone.0017286
Georgas, Kylie, Rumballe, Bree, Valerius, M. Todd, Chiu, Han Sheng, Thiagarajan, Rathi D., Lesieur, Emmanuelle, Aronow, Bruce J., Brunskill, Eric W., Combes, Alexander N., Tang, Dave, Taylor, Darrin, Grimmond, Sean M., Potter, S. Steven, McMahon, Andrew P. and Little, Melissa H. (2009).
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Developmental Biology, 332 (2), 273-286. doi: 10.1016/j.ydbio.2009.05.578
Combes, Alexander N., Lesieur, Emmanuelle, Harley, Vincent R., Sinclair, Andrew H., Little, Melissa H., Wilhelm, Dagmar and Koopman, Peter (2009).
Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Developmental Dynamics, 238 (5), 1033-1041. doi: 10.1002/dvdy.21925
Nairn, Kate M., Lyons, Russell E., Mulder, Roger J., Mudie, Stephen T., Cookson, David J., Lesieur, Emmanuelle, Kim, Misook, Lau, Deborah, Schole, Fiona H. and Elvin, Christopher M. (2008).
A synthetic resilin is largely unstructured. Biophysical Journal, 95 (7), 3358-3365. doi: 10.1529/biophysj.107.119107
Georgas, Kylie, Rumballe, Bree, Wilkinson, Lorine, Chiu, Han Sheng, Lesieur, Emmanuelle, Gilbert, Thierry and Little, Melissa H. (2008).
Use of dual section mRNA in situ hybridization/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney. Histochemistry and Cell Biology, 130 (5), 927-942. doi: 10.1007/s00418-008-0454-3
Lyons, Russell E., Lesieur, Emmanuelle, Kim, Misook, Wong, Darren C. C., Huson, Mickey G., Nairn, Kate M., Brownlee, Alan G., Pearson, Roger D. and Elvin, Christopher M. (2007).
Design and facile production of recombinant resilin-like polypeptides: gene construction and a rapid protein purification method. Protein Engineering Design & Selection, 20 (1), 25-32. doi: 10.1093/protein/gzl050
Copyright © 2017 - The University of Queensland