Jared Coombs
Jared Coombs
(he, him)
PhD student
Inflammasome Lab
Jared joined the Inflammasome Lab in 2019 for an undergraduate research project. In 2021, he undertook an Honours project that explored the hyperactivation mechanisms of NLRP3, the catalyst for a group of rare but severe genetic autoinflammatory diseases, and investigated novel small molecule inhibitors to treat such diseases. Jared’s research earned him First Class Honours. Jared stayed on as a research assistant in 2022, before commencing his PhD in January 2023 as an IMB Global Challenges scholar. His PhD project will examine the role of inflammasomes in wound healing and explore novel therapeutics for chronic, unhealing wounds.
"Research is to see what everybody else has seen, and to think what nobody else has thought”
Albert Szent-Györgyi
CONTACTS AND LINKS
Email: j.coombs@uq.edu.au
Office Telephone: +61 7 3346 2356
AWARDS AND PUBLICATIONS
AWARDS, GRANTS AND PRIZES
2025 IMB PhD Student Conference Travel Award, Institute for Molecular Bioscience, The University of Queensland, Australia
2023 IMB Global Challenges Scholarship, Institute for Molecular Bioscience, The University of Queensland, Australia
2023 Dorothy Hill PhD Scholarship, The University of Queensland, Australia
2023 Patricia Byrne Top Up Scholarship in Clean Energy Research, The University of Queensland, Australia
2021 University Medal, The University of Queensland, Australia
2020 Dean’s Commendation for Academic Excellence, The University of Queensland, Australia
2019 Dean’s Commendation for Academic Excellence, The University of Queensland, Australia
2018 Dean’s Commendation for Academic Excellence, The University of Queensland, Australia
2018 Merit Scholarship, The University of Queensland, Australia
EDUCATION
2021 BSc Honours (Immunology), Supervisors: Prof Kate Schroder and Dr Stefan Emming, The University of Queensland, Australia
2020 BSc (Extended Biomedical Science Major), The University of Queensland, Australia
Pizzuto M, Monteleone M, Burgener SS, Began J, Kurera M, Chia JR, Frampton E, Crawford J, Oliveira M, Kenney KM, Coombs JR, Yamamoto M, Man SM, Broz P, Pelegrin P, Schroder K (2025).
Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11. EMBO Journal 44(16):4419-4442. Pubmed
Coombs JR, Burgener SS, Schroder K (2025).
Spectosis: Dying for a complement. Immunity 58(6):1372-1374. Pubmed
Holley CL, Monteleone M, Fisch D, Libert AES, Ju RJ, Choi JH, Condon ND, Emming S, Crawford J, Lawrence GMEP, Coombs JR, Lefevre JG, Bajracharya R, Lahoud MH, Yap AS, Hamilton N, Stehbens SJ, Kagan JC, Ariotti N, Burgener SS, Schroder K (2025).
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells. Nature Immunology 26(1):42-52. Pubmed
Holley CL, Emming S, Monteleone MM, Mellacheruvu M, Kenney KM, Lawrence GMEP, Coombs JR, Burgener SS, Schroder K (2024).
The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis. Cell Chemical Biology 31(5):962-972. Pubmed
Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K (2024).
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling 17(820):eabg8145. Pubmed
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