Jelena Bezbradica Mirkovic
Dr Jelena Bezbradica Mirkovic
Research Officer, Inflammasome Lab
Kennedy Trust for Rheumatology Research (KTRR) Fellow, Oxford University
Jelena is an Early Career Researcher within the Inflammasome Lab. Jelena received her PhD in Immunology from the laboratory of Professor Sebastian Joyce at Vanderbilt University in the USA, and completed her postdoctoral training in Immunology in the laboratory of Professor Ruslan Medzhitov at Yale University, USA. Jelena joined the laboratory of Dr Kate Schroder as a Research Officer in 2014. She is currently focusing her research efforts towards understanding the biology of inflammatory responses to sterile versus microbe-induced tissue injury. Jelena will be starting her own research group at Oxford University, UK in 2016. But before that, she enjoys working with fun and creative people from the Inflammasome Lab!
CONTACTS AND LINKS
Email: j.bezbradica@imb.uq.edu.au
Office Telephone: +61 7 3346 2100
Laboratory Telephone: +61 7 3346 2356
Institute for Molecular Bioscience
The University of Queensland, UQ Researcher
AWARDS AND PUBLICATIONS
AWARDS, GRANTS AND PRIZES
2016-2021 Senior Research Fellowship, Kennedy Trust for Rheumatology Research (KTRR), Oxford University, UK
2016-2019 NHMRC Project Grant, serving as Chief Investigator B, with Dr Kate Schroder as Chief Investigator A, The University of Queensland, Australia
2014-2015 Early Career Researcher Grant, The University of Queensland, Australia
2008-2011 Damon Runyon Cancer Research Foundation (DRCRF) Fellowship, USA
2008-2011 Howard Hughes Medical Institute (HHMI) Fellowship (named HHMI Fellow of the Damon Runyon Cancer Research Foundation; of 31 Damon Runyon fellows in 2008, 4 were selected by HHMI for funding), USA
2008 Cancer Research Institute (CRI) Fellowship; fellowship declined upon acceptance of DRCRF/HHMI fellowship, USA
2006 Outstanding Graduate Student Award, Sidney P. Colowick, Vanderbilt University
EDUCATION
2003–2006 Doctor of Philosophy in Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA. Thesis title: “Lineage commitment and functional differentiation of invariant natural T (iNKT) cells”. Laboratory of Professor Sebastian Joyce.
1996–2003 Bachelor of Science, The Faculty of Pharmacy, Department of Medical Biochemistry, University of Belgrade, Belgrade, Serbia.
ORIGINAL RESEARCH ARTICLES
Bezbradica JS1, Coll R1, Schroder K (2016).
Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals. Cellular & Molecular Immunology. In press. 1Joint contribution.
Chen KW, Bezbradica JS, Gross CJ, Wall AA, Sweet MJ, Stow JL, Schroder K (2016).
The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists. European Journal of Immunology In press.
REVIEWS, COMMENTARIES AND BOOK CHAPTERS
Bezbradica JS, Schroder K (2014).
TRAF6 is a nexus for TLR-STAT1 crosstalk. Immunology and Cell Biology 92: 737-738. Pubmed
Comment on:
STAT1 plays a role in TLR signal transduction and infammatory responses. Luu K et al 2014 Immunol Cell Biol.
Spencer, C.T., Bezbradica, J.S., Ramos, M.G., Arico, C.D., Conant, S.B., Gray, J.J., Zheng, M., Niu, N., Hildebrand, W., Link, A.J. and Joyce, S (2015).
Viral infection causes a shift in self peptide repertoire presented by human MHC class I molecule, Proteomics-Clinical Applications, 9: 1035-1052.
Bezbradica, J.S., Rosenstein, R.K., DeMarco, R.A., Brodsky, I., Medzhitov, R (2014).
A role for the ITAM signaling module in specifying cytokine-receptor functions, Nature Immunology, 15: 333-342
Rosenstein, R.K., Bezbradica, J.S., Yu, S., Medzhitov, R. (2014).
Innate Immune Signaling of Protease Allergens. Proc. Natl. Acad. Sci. USA, 111: E4963-4971
Paduraru, C., Bezbradica, J.S., Kunte, A., Kelly, R., Shayman, J.A, Veerapen, N., Cox, L.R., Besra, G.S., Cresswell, R. (2013).
A Role for Lysosomal Phospholipase A2 in NKT Cell-Mediated CD1d Recognition, Proc. Natl. Acad. Sci. USA, 110: 5097-5102
Bezbradica J.S. and Medzhitov R., (2012).
Role of ITAM signaling module in signal integration, Current Opinion in Immunology, 24:58-66 (review)
Gordy L.E., Bezbradica, J.S., Flyak, A.I., Spencer, C.T., Dunkle, A., Florence, W.C., Stanic, A. K., Sun, J., Zhou, Z., He, Y-W., Boothby, M.R., Van Kaer, L. and Joyce, S (2011).
IL-15 regulates homeostasis and terminal maturation of NKT cells. J. Immunol. 187:6335-6345
Bezbradica J.S. and Medzhitov R., (2009).
Integration of cytokine and heterologous receptor signaling pathways, Nature Immunology 10:333-339 (review)
Villarino, A.V., Artis, D., Bezbradica, J.S., Miller, O., Saris, C.J.M., Joyce, S., Scott, P., and Hunter, C.A., (2008).
IL-27 receptor-deficiency results in delayed mortality and protection from helminth-induced pathology in a model of chronic IBD, International Immunology, 20:739-752
Horng T., Bezbradica J.S., and Medzhitov R. (2007).
NKG2D signaling is coupled with the IL-15 receptor signaling pathway, Nature Immunology, 8:1345-1352
Torres, V.J., Stauff, D.L., Pishchany, G., Bezbradica, J.S., Gordy, L.E., Iturregui, J., Anderson, K.L., Dunman, P.M., Joyce, S., and Skaar, E.P., (2007).
A Staphylococcus aureus Regulatory System that Responds to Host Heme and Modulates Virulence. Cell Host and Microbe, 1:109-119
Bezbradica, J.S., Gordy, L.E., Stanic, A.K., Dragovic, S., Hill, T., Hawiger, J., Unutmaz, D., Van Kaer, L., Joyce, S. (2006).
Granulocyte-macrophage colony-stimulating factor regulates effector differentiation of invariant natural killer T cells during thymic ontogeny, Immunity, 25:487-497
Bezbradica, J.S.1, Hill, T.1, Stanic, A.K., Van Kaer, L., Joyce, S (2005).
Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc. Natl. Acad. Sci. USA, 102: 5114-5119. 1Joint contribution.
Bezbradica, J.S., Stanic, A.K., Matsuki, N., Bour-Jordan, H., Bluestone, J.A., Thomas, J.W., Unutmaz, D., Van Kaer, L. and Joyce, S (2005).
Distinct roles of dendritic cells and B cells in Va14Ja18 natural T (iNKT) cell activation in vivo. J. Immunol. 174: 4696-4705
Stanic, A.K., Bezbradica, J.S., Park, J.J., Matsuki, N., Mora, A.L., Van Kaer, L., Boothby, M.R., Joyce, S (2004).
NF-kB controls cell fate specification, survival, and molecular differentiation of immunoregulatory natural T lymphocytes. J. Immunol. 172: 2265-2273
Stanic, A.K., Bezbradica, J.S., Park, J.J., Van Kaer, L., Boothby, M.R., Joyce, S (2004).
The ontogeny and function of Va14Ja18 natural T lymphocytes require signal processing by protein kinase C-q and NF-kB. J. Immunol. (Cutting Edge), 172: 4667-4671
Stanic, A.K., Shashidharamurthy, R., Bezbradica, J.S., Matsuki, N., Yoshimura, Y., Miyake, S., Choi, E.Y., Schell, T.D., Van Kaer, L., Tevethia, S.S., Roopenian, D.C., Yamamura, T., Joyce, S. (2004).
Another view of T cell antigen recognition: cooperative engagement of glycolipid antigens by Va14Ja18 natural T (iNKT) cell receptor. J. Immunol. 171: 4539-4551
Parekh, V.V., Singh, A.K., Wilson, M.T., Olivares-Villagomez, D. Bezbradica, J.S., Sanazawa, H., Ehara, H., Sakai, T., Serizava, I.,Wu, L., Wang, C., Joyce, S., Van Kaer, L. (2004).
Quantitative and qualitative differences in the in vivo response of NKT cells to distinct a- and b-anomeric glycolipids. J. Immunol. 173: 3693-3706
Nakai, Y., Iwabuchi, K., Fujii, S., Ishimori, N., Dashtsoodol, N., Watano, K., Mishima, T., Iwabuchi, C., Tanaka, S., Bezbradica, J.S., Nakayama, T., Taniguchi, M., Miyake, S., Yamamura, T., Kitabatake, A., Joyce, S., Van Kaer, L., Onoe, K. (2004).
Natural killer T cells accelerate atherogenesis in mice. Blood, 104: 2051-2059
Saito, T., Okumura, A., Watanabe, H., Asano, M., Ishida-Okawara, A., Sakagami, J., Sudo, K., Hatano-Yokoe, Y., Bezbradica, J.S., Joyce, S., Abo, T., Iwakura, Y., Suzuki, K., Yamagoe, S. (2004).
Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis. J. Immunol, 173: 579-585
REVIEWS AND BOOK CHAPTERS
Hill, T.M., Bezbradica J.S., Van Kaer, L., and Joyce, S., (2015).
CD1d-restricted Natural Killer T cells (version 2.0). Encyclopedia of Life Sciences (ELS), Unit A26153, an update on previously published Unit A20180 (John Wiley & Sons, Inc., USA), book chapter, DOI: 10.1002/9780470015902.a0020180.pub2.
Bezbradica J.S., Van Kaer, L., and Joyce, S., (2007).
Natural Killer T cells. Encyclopedia of Life Sciences (ELS), Unit A20180, (John Wiley & Sons, Inc., USA), book chapter
Bezbradica J.S., Stanic A.K., and Joyce, S. (2006).
Characterization and functional analysis of murine invariant natural T (iNKT) cells. Current Protocols in Immunology, CPI Unit 14.13, Section: Innate Immunity (John Wiley & Sons, Inc., USA), book chapter
Bezbradica, J.S., and Joyce, S. (2005).
Natural T lymphocytes and dendritic cells: An innate duet that arouses and tempers immune responses. Altered Immunoregulation and Human Disease, R. M. Gorczynski, ed. (Trivandrum, India, Research Signpost), pp. 137-163, book chapter
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