Manasa Mellacheruvu

 

Manasa Mellacheruvu

(she, her)
 
PhD student
Inflammasome Lab

 

 

Manasa completed a Bachelor of Science (2014-2017) with Microbiology and Biochemistry as core subjects from St. Francis College, Hyderabad, India. Her interest in Innate Immunity and Signalling Pathways started during her Master’s program in Immunobiology (2017-2019) where she pursued her research (Master Thesis) at the Institute of Innate Immunity, University of Bonn, Germany in Prof. Eicke Latz’s lab. Her research in Prof. Latz’s lab aimed to elucidate the molecular mechanisms of NLRP3 inflammasome activation by investigating how Reactive Oxygen Species affects NLRP3 activation status. Manasa’s research continued in the field as she worked as a Research Assistant in Prof. Latz’s lab until June 2020. Manasa commenced her PhD in the Inflammasome Lab in 2022. Her research focuses on elucidating the mechanisms of activation of inflammasomes, assembled by Nod-like receptors, to understand their structure and conformation in physiological and active states and their suitability as anti-inflammatory drug targets.

 

I am young and I have a dream, a dream to dream big, aim high and achieve what I propose to achieve.

Manasa Mellacheruvu

 

CONTACTS AND LINKS

 

Email: m.mellacheruvu@uq.edu.au

Office Telephone: +61 7 3346 2356

 

Institute for Molecular Bioscience

ORCID

 

AWARDS AND PUBLICATIONS

 

 

AWARDS, GRANTS AND PRIZES

 

2017 In Vivo Gold Medal (student graduating with highest marks in Biochemistry), Department of Biochemistry, St. Francis College, Hyderabad, India

2017 Founders Prize Gold Medal in Biochemistry (student graduating with highest marks in Biochemistry), St. Francis College, Hyderabad, India

2017 First Prize for Proficiency in Academics (student with the highest aggregate score), St. Francis College, Hyderabad, India

2016 Second Prize for Proficiency in Academics (student with the second highest aggregate score), St. Francis College, Hyderabad, India

 

EDUCATION

 

2019  MSc, University of Bonn, Germany

2017 BSc, St. Francis College, Hyderabad, India

 

 

Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K (2024).
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling 17(820):eabg8145. Pubmed

 

Mellacheruvu M, Lawrence GMEP, Emming S, Schroder K (2023).
Reversing the mitochondrial hex that bewitches NLRP3. Science Immunology 8(84):eadh2967. Pubmed