Manasa Mellacheruvu
Manasa Mellacheruvu
(she, her)
PhD student
Inflammasome Lab
Manasa completed a Bachelor of Science (2014-2017) with Microbiology and Biochemistry as core subjects from St. Francis College, Hyderabad, India. Her interest in Innate Immunity and Signalling Pathways started during her Master’s program in Immunobiology (2017-2019) where she pursued her research (Master Thesis) at the Institute of Innate Immunity, University of Bonn, Germany in Prof. Eicke Latz’s lab. Her research in Prof. Latz’s lab aimed to elucidate the molecular mechanisms of NLRP3 inflammasome activation by investigating how Reactive Oxygen Species affects NLRP3 activation status. Manasa’s research continued in the field as she worked as a Research Assistant in Prof. Latz’s lab until June 2020. Manasa commenced her PhD in the Inflammasome Lab in 2022. Her research focuses on elucidating the mechanisms of activation of inflammasomes, assembled by Nod-like receptors, to understand their structure and conformation in physiological and active states and their suitability as anti-inflammatory drug targets.
CONTACTS AND LINKS
Email: m.mellacheruvu@uq.edu.au
Office Telephone: +61 7 3346 2356
Institute for Molecular Bioscience
AWARDS AND PUBLICATIONS
AWARDS, GRANTS AND PRIZES
2017 In Vivo Gold Medal (student graduating with highest marks in Biochemistry), Department of Biochemistry, St. Francis College, Hyderabad, India
2017 Founders Prize Gold Medal in Biochemistry (student graduating with highest marks in Biochemistry), St. Francis College, Hyderabad, India
2017 First Prize for Proficiency in Academics (student with the highest aggregate score), St. Francis College, Hyderabad, India
2016 Second Prize for Proficiency in Academics (student with the second highest aggregate score), St. Francis College, Hyderabad, India
EDUCATION
2019 MSc, University of Bonn, Germany
2017 BSc, St. Francis College, Hyderabad, India
Coombs JR, Zamoshnikova A, Holley CL, Maddugoda MP, Teo DET, Chauvin C, Poulin LF, Vitak N, Ross CM, Mellacheruvu M, Coll RC, Heinz LX, Burgener SS, Emming S, Chamaillard M, Boucher D, Schroder K (2024).
NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling 17(820):eabg8145. Pubmed
Mellacheruvu M, Lawrence GMEP, Emming S, Schroder K (2023).
Reversing the mitochondrial hex that bewitches NLRP3. Science Immunology 8(84):eadh2967. Pubmed
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