Nod-like Receptor and Inflammasome Activation Mechanisms

Project Description

Inflammasomes are assembled by innate immune receptor proteins (e.g. Nod-like receptors) but the underlying molecular mechanisms are largely unknown. We seek to understand how inflammasome scaffolds sense cellular ‘danger’ signals, and nucleate the formation of inflammasome complexes.



  • Mechanisms of NLRP3 activation
  • Molecular determinants of inflammasome assembly


Select Publications:

  1. Coll RC, Hill JR, Day CJ, Zamoshnikova A, Boucher D, Massey NL, Chitty JL, Fraser JA, Jennings MP, Robertson AAB, Schroder K (2019).
    MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition. Nature Chemical Biology 15(6):556-559. PDF Pubmed
  2. Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS and Schroder K. (2018).
    Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine 215(3):827-840. 1Joint contribution. Pubmed
  3. Bezbradica JS1, Coll R1, Schroder K (2017).
    Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals. Cellular & Molecular Immunology. 14:118-126. 1Joint contribution. Pubmed
  4. Chen KW, Bezbradica JS, Gross CJ, Wall AA, Sweet MJ, Stow JL, Schroder K (2016).
    The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists. European Journal of Immunology 46(4):1004-10. Pubmed
  5. Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AA, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O. (2016).
    K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting  Mitochondria. Immunity. Oct 18;45(4):761-773. Pubmed
  6. Baker PJ1, Boucher D1, Bierschenk D, Tebartz C, Whitney PG, D'Silva DB, Tanzer MC, Monteleone M, Robertson AA, Cooper MA, Alvarez-Diaz S, Herold MJ, Bedoui S, Schroder K2, Masters SL2 (2015).
    NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5. European Journal of Immunology 45:2918-26. 1, 2Joint Contribution. Pubmed
  7. Guarda G, Zenger M, Yazdi AS, Schroder K, Ferrero I, Menu P, Tardivel A, Mattmann C, & Tschopp J (2011).
    Differential expression of NLRP3 among hematopoietic cells. Journal of Immunology 186(4):2529-2534. Pubmed
  8. Schroder K, Zhou R, & Tschopp J (2010).
    The NLRP3 inflammasome: a sensor for metabolic danger? Science 327(5963):296-300. Pubmed
  9. Tschopp J & Schroder K (2010).
    NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nature Reviews Immunology 10(3):210-215. Pubmed
  10. Schroder K, Muruve DA, & Tschopp J (2009).
    Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. Current Biology 19(6):R262-265. Pubmed


Image: Artwork represents an activated inflammasome.

In vivo biology
Molecular biology
Cell biology