Discovery

Major research discoveries, ususally linked to a high profile publication.

The Inflammasome Lab have discovered that neutrophils can signal via TNFR1-driven ripoptosome assembly to induce both cell death and IL-1β maturation, but suppress TLR4-dependent cell death and NLRP3 inflammasome activation during IAP inhibition,

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Inflammasome signalling animation

The Inflammasome Lab have uncovered precisely how caspase-1 is activated upon inflammasomes, which has revealed a new model for inflammasome signalling, function, and signal shutdown.

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The Inflammasome Lab have uncovered precisely how caspase-1 is activated upon inflammasomes, which has revealed a new model for inflammasome signalling, function, and signal shutdown.

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Inflammasome special issue

The inflammasome special issue of Journal of Molecular Biology, co-edited by Kate Schroder, Thirumala-Devi Kanneganti, Feng Shao and Petr Broz, is now online.

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Farewell to Kaiwen and Cookie

This month we said farewell to Kaiwen Chen, who leaves the Inflammasome Lab for an exciting Postdoctoral position in Petr Broz's Lab in Switzerland, and Jennifer (Cookie) Dou who is embarking on an exciting new career in animation.

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Jelena Bezbradica, Rebecca Coll and

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Kaiwen Chen, Jelena Bezbradica and

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Congratulations to Dr Rebecca Coll, for publishing her research, characterising a small-molecule inhibitor of the NLRP3 inflammasome, in the prestigious journal Nature Medicine.

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