Discovery

Major research discoveries, ususally linked to a high profile publication.

Mark Milner et al.

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Caroline Holley and Kate Schroder from the Inflammasome Lab published a review in Clinical and Translational Immunology this month highlighting the importance of a holistic approach to investigations of NLRP3 activation b

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Sabrina Sofia Burgener and Kate Schroder from the Inflammasome Lab have published a review in the Journal of Experimental Medicine this month on how the placenta is a dynamic immunological organ.  

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Amy Chan and Kate Schroder from the Inflammasome Lab provided an updated view of inflammasome signaling; mechanisms underpinning IL-1α,IL-1β, IL-18, and IL-37maturation and release; and the functions of these cytokines in protective and pathologic

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The Inflammasome Lab is thrilled to have contributed to the development NLRP3 inhibitors, now under translation to the clinic by Roche for treatment of inflammatory and neurodegenerative diseases.

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The Inflammasome lab is thrilled that NLRP3 inflammasome inhibitors are now in Phase II in clinical trials with Inflazome.

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Sabrina Sofia Burgener and Kate Schroder from the Inflammasome Lab have published a perspective in Cold Spring Harb Perspect Biol. In it they "review the signaling mechanisms and cell biology underpinning the key NETosis

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Stefan Emming and Kate Schroder from the Inflammasome Lab have published a review in Science magazine this month on how "Multiple DNA sensors (TLR9, hnRNP-A2B1, cGAS, and AIM2) in different cellular compartments may allow

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The Inflammasome Lab have defined the molecular target of MCC950, revealing the mechanism by which this potent and specific small-molecule inhibitor inhibits the NLRP3 inflammasome.  

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The Inflammasome Lab have discovered a new pathway for host defence against cytosolic Gram-negative bacteria, revealing unexpected links between pyroptosis and NETosis.

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