Discovery

Major research discoveries, ususally linked to a high profile publication.

Stefan Emming and Kate Schroder from the Inflammasome Lab have published a review in Science magazine this month on how "Multiple DNA sensors (TLR9, hnRNP-A2B1, cGAS, and AIM2) in different cellular compartments may allow

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The Inflammasome Lab have defined the molecular target of MCC950, revealing the mechanism by which this potent and specific small-molecule inhibitor inhibits the NLRP3 inflammasome.  

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The Inflammasome Lab have discovered a new pathway for host defence against cytosolic Gram-negative bacteria, revealing unexpected links between pyroptosis and NETosis.

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Here the Inflammasome Lab reveal that Salmonella evades immune response by subverting the NLRP3 and NLRC4 inflammasome in macrophages.

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The Inflammasome Lab have discovered a new pathway for host defence against cytosolic Gram-negative bacteria, revealing unexpected links between pyroptosis and NETosis.

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New research from Inflammasome Lab reveals trafficking mechanisms driving the unconventional secretion of mature interleukin-1β in non-pyroptotic and pyroptotic myeloid cells, and functions for caspase-1 and Gasdermin-D therein.

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The lab celebrated new paper acceptances with a pub crawl of Brisbane's finest establishments in West End on Friday. Congratulations to everyone in the Inflammasome Lab, and to our wonderful overseas collaborators!

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The Inflammasome Lab is thrilled to have our recent research featured in the Journal of Experimental Medicine special collection.  

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This month we farewell Damiën Bierschenk, who leaves the Inflammasome Lab for Sweden after submitting his PhD thesis.

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The Inflammasome Lab have discovered that neutrophils can signal via TNFR1-driven ripoptosome assembly to induce both cell death and IL-1β maturation, but suppress TLR4-dependent cell death and NLRP3 inflammasome activation during IAP inhibition,

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