Neutrophil Nod-like Receptors and Inflammasomes

Project Description

Neutrophils are innate immune cells with key functions in antimicrobial host defence, but their ability to signal via pattern recognition receptor pathways is poorly characterised. We are characterising new roles for neutrophils in Nod-like receptor and inflammasome signalling in vivo, and seek to understand how cell identity shapes neutrophil immune signalling pathways.

 

Projects:

  • Inflammasome activation in neutrophils
  • Neutrophil inflammasomes in host defence against infection
  • Neutrophil inflammasomes in inflammatory disease pathology
  • Neutrophil-specific NLRs and PRRs

 

Select Publications:

 

  1. Boucher D, Monteleone M1, Coll RC1, Chen KW1, Ross CM, Teo JL, Gomez GA, Holley CL, Bierschenk D, Stacey KJ, Yap AS, Bezbradica JS and Schroder K. (2018).
    Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity. Journal of Experimental Medicine 215(3):827-840. 1Joint contribution. Pubmed
     
  2. Chen KW, Lawlor KE, von Pein JB, Boucher D, Gerlic M, Croker BA, Bezbradica J, Vince JE, Schroder K. (2018).
    IAP inhibition sensitizes neutrophils to TNF but not LPS-mediated cell death and IL-1β secretion. Journal of Immunology In press.
     
  3. Chen KW, Bezbradica JS, Gross CJ, Wall AA, Sweet MJ, Stow JL, Schroder K (2016).
    The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists. European Journal of Immunology 46(4):1004-10. Pubmed
     
  4. Zamoshnikova A, Groß CJ, Schuster S, Chen KW, Wilson A, Tacchini-Cottier F, Schroder K (2016).
    NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling. Immunobiology 221(2):341-6. Pubmed
     
  5. Chen KW, Gross CJ, Sotomayor F, Stacey KJ, Tschopp J, Sweet MJ, Schroder K (2014).
    The neutrophil NLRC4 inflammasome selectively promotes IL-1b maturation without pyroptosis during acute Salmonella challenge. Cell Reports 8: 570-582. Pubmed
     
  6. Thomas CJ, Schroder K (2013).
    Pattern recognition receptor function in neutrophils. Trends in Immunology 34:317-328. Pubmed

 

Image: Artwork represents neutrophil cells and their multi-lobed nuclei.

 

Categories: 
In vivo biology
Microbiology
Molecular biology
Cell biology