Caroline Holley and Kate Schroder from the Inflammasome Lab published a review in Clinical and Translational Immunology this month highlighting the importance of a holistic approach to investigations of NLRP3 activation b
Sabrina Sofia Burgener and Kate Schroder from the Inflammasome Lab have published a review in the Journal of Experimental Medicine this month on how the placenta is a dynamic immunological organ.
Amy Chan and Kate Schroder from the Inflammasome Lab provided an updated view of inflammasome signaling; mechanisms underpinning IL-1α,IL-1β, IL-18, and IL-37maturation and release; and the functions of these cytokines in protective and pathologic
The Inflammasome Lab is thrilled to have contributed to the development NLRP3 inhibitors, now under translation to the clinic by Roche for treatment of inflammatory and neurodegenerative diseases.
Sabrina Sofia Burgener and Kate Schroder from the Inflammasome Lab have published a perspective in Cold Spring Harb Perspect Biol. In it they "review the signaling mechanisms and cell biology underpinning the key NETosis
Stefan Emming and Kate Schroder from the Inflammasome Lab have published a review in Science magazine this month on how "Multiple DNA sensors (TLR9, hnRNP-A2B1, cGAS, and AIM2) in different cellular compartments may allow
The Inflammasome Lab have defined the molecular target of MCC950, revealing the mechanism by which this potent and specific small-molecule inhibitor inhibits the NLRP3 inflammasome.
The Inflammasome Lab have discovered a new pathway for host defence against cytosolic Gram-negative bacteria, revealing unexpected links between pyroptosis and NETosis.
