Neutrophil Extracellular Traps in Host Defense.

Sabrina Sofia Burgener and Kate Schroder from the Inflammasome Lab have published a perspective in Cold Spring Harb Perspect Biol. In it they "review the signaling mechanisms and cell biology underpinning the key NETosis pathways during infection and the antimicrobial functions of NETs in host defense."

 

Burgener SS, Schroder K. (2019).
Neutrophil Extracellular Traps in Host Defense. Cold Spring Harbor Perspectives in Biology 2019 Nov 25;a037028. doi: 10.1101/cshperspect.a037028. Online ahead of print. Pubmed

 

Abstract
Neutrophils are produced in the bone marrow and then patrol blood vessels from which they can be rapidly recruited to a site of infection. Neutrophils bind, engulf, and efficiently kill invading microbes via a suite of defense mechanisms. Diverse extracellular and intracellular microbes induce neutrophils to extrude neutrophil extracellular traps (NETs) through the process of NETosis. Here, we review the signaling mechanisms and cell biology underpinning the key NETosis pathways during infection and the antimicrobial functions of NETs in host defense. .

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ABOUT Inflammasome Lab

Inflammasome Lab is a group of researchers led by Dr Kate Schroder at the Institute for Molecular Bioscience, The University of Queensland.
We seek to unravel the secrets of inflammasomes – protein complexes at the heart of inflammation and disease – to allow for new therapies to fight human diseases.